Results 151 to 160 of about 1,622 (169)

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia‐reperfusion injury

FASEB Journal, 2017
ABSTRACT The complement system, and specifically C5a, is involved in renal ischemia‐reperfusion (IR) injury. The 2 receptors for complement anaphylatoxin C5a (C5aR1 and C5aR2) are expressed on leukocytes as well as on renal epithelium. Extensive evidence shows that C5aR1 inhibition protects kidneys from IR injury;
Felix Poppelaars, Juha Kotimaa, Albertina Ausema   +2 more
exaly   +7 more sources

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Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice

Thrombosis and Haemostasis, 2015
SummaryAtherogenic processes and vascular remodelling after arterial injury are controlled and driven by a plethora of factors amongst which the activation of the complement system is pivotal. Recently, we reported a clear correlation between high expressions of the second receptor for complement anaphylatoxin C5a, the C5a receptor-like 2 (C5L2, C5aR2),
Selle, Jaco, Asare, Yaw, Kohncke, Janine, Alampour-Rajabi, Setareh, Shagdarsuren, Gansuvd, Klos, Andreas, Weber, Christian, Jankowski, Joachim, Shagdarsuren, Erdenechimeg   +8 more
openaire   +3 more sources

Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2

Journal of Cellular Biochemistry, 2022
AbstractThe complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments that interacts with a distinct set of complement receptors.
Aurosikha Das, Manaswini Ghosh, Pulkit Kr. Gupta, Soumendra Rana   +3 more
openaire   +2 more sources

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma

FASEB Journal, 2019
ABSTRACT The canonical complement component 5a (C5a) receptor (C5aR) 1 has well‐described roles in tumorigenesis but the contribution of the second receptor, C5aR2, is unclear. The present study demonstrates that B16.F0 melanoma cells express mRNA for both C5aR1 and
Jamileh A Nabizadeh, Helga D Manthey, Frederik J Steyn   +2 more
exaly   +5 more sources

Igniting the flame in arthritis: C5aR2 controls endothelial transcytosis of C5a

Science Immunology, 2019
C5aR2 transfers arthritic joint-derived C5a to the blood vessel endothelium to start C5aR1-driven neutrophilic inflammation. See related Research Article by Miyabe et al .
openaire   +2 more sources

The Role of the C5a Receptor, C5aR2, in Neurodegenerative Disease

2017
There is increasing evidence that chronic complement activation is involved in numerous neurodegenerative disease states. Parkinson’s disease (PD) and Huntington’s disease (HD) are intractable neurodegenerative diseases characterised by progressive motor and cognitive dysfunction.
openaire   +3 more sources

Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation

Science Immunology, 2019
C5aR2 transports C5a into the blood vessel lumen to initiate neutrophil arrest in a murine model of arthritis.
Yoshishige Miyabe, Chie Miyabe, Vinidhra Mani, Thorsten R. Mempel, Andrew D. Luster   +4 more
openaire   +2 more sources

Differential effects of anaphylatoxin C5a on antigen presenting cells, roles for C5aR1 and C5aR2

Immunology Letters, 2019
The anaphylatoxin C5a is well-known for its role as chemoattractant and contributes to immune cell recruitment into inflamed tissue and local inflammation. C5a has recently been implicated in modulation of antigen presenting cell function, such as macrophages and dendritic cells, which are pivotal for T cell activation and final T cell effector ...
Zaal, A., van Ham, S.M., ten Brinke, Anja   +2 more
openaire   +4 more sources

Complement receptors C5aR1 and C5aR2 differentially influence bone metabolism

2017
Objectives: Activation of the complement system, a crucial arm of innate immunity, leads to the generation of the anaphylatoxin C5a, acting via its receptors C5aR1 and C5aR2. C5aR1 has already been attributed an important role in bone development, regeneration and inflammation, as C5aR1 expression on[for full text, please go to the a.m. URL]
Hägele, Y, Bergdolt, S, Matthes, R, Kovtun, A, Ignatius, A   +4 more
openaire   +2 more sources

Cell type specific accessibility of C5aR2 on human blood cells of myeloid origin

5.3 Allergy and Immunology, 2016
The complement anaphylatoxin C5a is a critical mediator of innate immunity and inflammation. Two G-protein coupled receptors (GPCR) have been described to bind C5a: The C5a receptor (C5aR/C5aR1) and the C5a receptor like-2 (C5L2/C5aR2). In contrast to C5aR1, the role of C5aR2 in C5a-mediated responses remains unclear.
Kistler Barbara, Schlegel Alexandra, Grauert Matthias, Arndt Kirsten, Williams Cara   +4 more
openaire   +1 more source