Results 141 to 150 of about 1,622 (169)

The role of complement in normal pregnancy and preeclampsia. [PDF]

Front Immunol
Burwick RM, Java A, Regal JF.
europepmc   +1 more source

Targeting C3a and C5a Signaling-A Game Changer for Cancer Therapy? [PDF]

Biology (Basel)
Hudgins H, Molina V, Wiernicki S, Okwuegbe K, Feng X, Wang H.   +5 more
europepmc   +1 more source

DAMP signaling networks: from receptors to diverse pathophysiological functions. [PDF]

J Adv Res
Chen R, Zou J, Zhong X, Liu J, Kang R, Tang D.   +5 more
europepmc   +1 more source

Complement biosynthesis in human brain: Insights from single-nucleus transcriptomics of hippocampus

Nguyen VD, Bright M, Zhou Y, Morgan BP, Zelek WM.   +4 more
europepmc   +1 more source

The heart-bone connection: relationships between myocardial infarction and osteoporotic fracture.

Am J Physiol Heart Circ Physiol
Tjandra PM, Ripplinger CM, Christiansen BA.   +2 more
europepmc   +1 more source

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C5aR2 receptor: The genomic twin of the flamboyant C5aR1

Journal of Cellular Biochemistry, 2022
AbstractThe complement fragment C5a is one of the most potent proinflammatory glycoproteins liberated by the activation of the biochemical cascade of the complement system. C5a is established to interact with a set of genomically related transmembrane receptors, like C5aR1 (CD88, C5aR) and C5aR2 (GPR77, C5L2) with comparable affinity.
Soumendra Rana
exaly   +3 more sources

C5aR2

2018
The second receptor for C5a is a new addition to the complement family since the first edition of this book. It was discovered in 2000 and, despite its relatively short history, its function has been the subject of controversy. The genetic locus for this receptor consists of two exons separated by a large intron, a structure it shares with C5aR1. C5aR2
Liam G Coulthard, Owen A Hawksworth, Trent M Woodruff   +2 more
exaly   +5 more sources

The C5a/C5aR2 axis promotes renal inflammation and tissue damage [PDF]

JCI Insight, 2020
C5a is a potent inflammatory mediator that binds C5aR1 and C5aR2. Although pathogenic roles of the C5a/C5aR1 axis in inflammatory disorders are well documented, the roles for the C5a/C5aR2 axis in inflammatory disorders and underlying mechanisms remain unclear. Here, we show that the C5a/C5aR2 axis contributes to renal inflammation and tissue damage in
Ting Zhang, Kun-Yi Wu, Malgorzata A Garstka   +2 more
exaly   +3 more sources

Ternary model structural complex of C5a, C5aR2, and β-arrestin1

Journal of Biomolecular Structure and Dynamics, 2023
Complement component fragment 5a (C5a) is one of the potent proinflammatory modulators of the complement system. C5a recruits two genomically related G protein-coupled receptors (GPCRs), like C5aR1 and C5aR2, constituting a binary complex. The C5a-C5aR1/C5aR2 binary complexes involve other transducer proteins like heterotrimeric G-proteins and β ...
Pulkit Kr, Gupta, Aurosikha, Das, Aditi, Singh, Soumendra, Rana   +3 more
openaire   +2 more sources

Double Deletion of C5aR1 and C5aR2 during Streptococcal Pneumonia

The Journal of Immunology, 2020
Abstract The complement system is essential for the clearance of encapsulated bacteria such as Streptococcus pneumoniae (Spn), recognized as a major pathogen of pneumonia. Yet, it is not entirely clear whether C5 and its activation product C5a have beneficial or detrimental effects on the outcome of Spn infection.
Sarah Walachowski, Markus Dudek, Leonid Eshkind, Vanessa Tansi, Joseph P Mizgerd, Markus Bosmann   +5 more
openaire   +1 more source