Results 91 to 100 of about 202,389 (291)

Ca2+ homeostasis in unstimulated platelets.

Journal of Biological Chemistry, 1984
Unstimulated platelets maintain a low cytosolic free Ca2+ concentration and a steep plasma membrane Ca2+ gradient. The mechanisms that are required have not been completely defined. In the present studies, 45Ca2+ was used to examine the kinetics of Ca2+ exchange in intact unstimulated platelets.
openaire   +2 more sources

Transcription-independent effects of TGF-B on mitochondrial Ca2+ homeostasis [PDF]

, 2011
The rapid response of mitochondria to cellular Ca2+ signals depends on their close proximity to the ER, allowing them to sense microdomains of high [Ca2+] meeting the low affinity of the mitochondrial Ca2+ uniporter (MCU) of the inner membrane.
Siviero, Roberta
core  

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data [PDF]

, 2012
Background: Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).
Günter AJ Riegger, Sabine Fredersdorf, Vetter, Roland, Eschenhagen, Thomas, Weil, Joachim, Joachim Weil, Thumann, Christian, Wolfram H Zimmermann, Heribert Schunkert, Riegger, Günter A. J., Luchner, Andreas, Luchner Andreas, Vetter Roland, Zimmermann, Wolfram-Hubertus, Graf, Tobias, Schunkert, Heribert, Thumann Christian, Andreas Luchner, Weil Joachim, Fredersdorf Sabine, Roland Vetter, Schunkert Heribert, Eschenhagen Thomas, Tobias Graf, Graf Tobias, Zimmermann, Wolfram H., Thomas Eschenhagen, Zimmermann Wolfram H, Christian Thumann, Riegger, Guenter A. J., Fredersdorf, Sabine, Riegger Günter AJ   +31 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice

Nature Communications
Cellular calcium (Ca2+)-regulating systems are compromised during aging-related disorders. Here, we show that disruption of Ca2+ homeostasis leads to the cytoplasmic accumulation of Ca2+ binding protein S100A6, which promotes Hutchinson-Gilford progeria ...
Weifang Xiang, Qianying Hu, Pingli Sun, Xiaohan Wu, Hui Jiang, Min Qu, Lei Li, Yu Wang, Zhiyao Wang, Xuan Liu, Jun Ma, Dahai Zhu, Hu Li, Yuanyi Wang, Yang Jiao, Baiqu Huang, Jun Lu, Xianling Cong, Wei Li, Yu Zhang   +19 more
doaj   +1 more source

Alzheimer’s Disease-associated peptide Aβ42 mobilises ER Ca2+ via InsP3R-dependent and -independent mechanisms

Frontiers in Molecular Neuroscience, 2013
Dysregulation of Ca2+ homeostasis is considered to contribute to the toxic action of the Alzheimer’s Disease (AD) associated Amyloid-β-peptide (Aβ). Ca2+ fluxes across the plasma membrane and release from intracellular stores have both been reported to ...
Laura E Allan, Geert eBultynck, Tomas eLuyten, Hozeefa eAmijee, Martin D Bootman, H Llewelyn eRoderick   +5 more
doaj   +1 more source

The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. [PDF]

, 2013
Ca(2+) contributes to a myriad of important cellular processes in all organisms, including the apicomplexans, Plasmodium and Toxoplasma. Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms.
Staines, Henry M., David S Guttery, Wheatley Sally P., Guttery, DS, Dominique Soldati-Favre (79026), Leon R. McFarlane (7795319), Sally P. Wheatley (7750238), Soldati-Favre, D, Pittman, Jon K, Tewari Rita, Jon K Pittman, Sally P. Wheatley (384069), Wheatley, Sally P., Frénal, K, Sanjeev Krishna (4917), Leon R McFarlane, Benoit Poulin (134241), Wheatley, SP, Frénal Karine, Dominique Soldati-Favre, Ksenija Slavic (384068), Karine Frénal, Staines, Henry M, Sanjeev Krishna, Guttery, David S, Poulin, Benoit, Frénal, Karine, McFarlane, Leon R, Rita Tewari, Karine Frénal (384066), Ksenija Slavic, Guttery, David S., Tewari, R, Tewari, Rita, Poulin Benoit, Pittman Jon K., Pittman, JK, Poulin, B, Rita Tewari (134257), Henry M Staines, Henry M. Staines (7795322), McFarlane, Leon R., Krishna Sanjeev, Soldati-Favre Dominique, Pittman, Jon K.; id_orcid, Slavic, Ksenija, McFarlane Leon R., Staines Henry M., McFarlane, LR, Jon K. Pittman (127550), Guttery David S., Staines, HM, Krishna, S, Slavic Ksenija, Krishna, Sanjeev, Slavic, K, David S. Guttery (134240), Sally P Wheatley, Leon R. McFarlane (384067), Henry M. Staines (384070), David S. Guttery (7629998), Soldati-Favre, Dominique, Benoit Poulin, Wheatley, Sally P   +63 more
core   +1 more source