Results 111 to 120 of about 202,389 (291)

Mechanisms of exercise-induced muscle damage and fatigue: Intracellular calcium accumulation

Journal of Physical Fitness and Sports Medicine, 2012
Contraction-induced compromise of muscle function and, in the extreme, muscle damage has been linked to loss of Ca2+ homeostasis and resultant sustained elevation of intracellular Ca2+ ([Ca2+]i).
Yutaka Kano, Takashi Sonobe, Tadakatsu Inagaki, Mizuki Sudo, David C Poole   +4 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

TMEM65-dependent Ca2+ extrusion safeguards mitochondrial homeostasis

Nature Communications
The bidirectional transport of Ca2+ into and out of mitochondria regulates metabolism, signaling, and cell fate. While influx is mediated by the Mitochondrial Calcium Uniporter (MCU) complex, efflux mechanisms are more diversified, involving Na⁺ or H ...
Massimo Vetralla, Lena Wischhof, Asrat Kahsay, Vanessa Cadenelli, Enzo Scifo, Beijia Xie, Miriana Sbrissa, Maëlle Sandhira Habert, Dan Ehninger, Rosario Rizzuto, Daniele Bano, Diego De Stefani   +11 more
doaj   +1 more source

SOD1 PREVENTS MOTOR NEURON DEATH INDUCED BY THE CYCAD NEUROTOXIN BETA-METHYLAMINO-L-ALANINE BY MODULATING PLASMA MEMBRANE TARGETS INVOLVED IN INTRACELLULAR Ca2+ HOMEOSTASIS

, 2018
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neurons. Although the incoming knowledge on the genetic aspects of the disease, the pathogenesis remains unknown.
Pannaccione A, De Flora A, Annunziato L, Boscia F, Secondo A, Petrozziello T, Tedeschi V, Bruzzone S   +7 more
core  

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Ca2+ homeostasis regulates Xenopus oocyte maturation.

, 2008
In contrast to the well-defined role of Ca2+ signals during mitosis, the contribution of Ca2+ signaling to meiosis progression is controversial, despite several decades of investigating the role of Ca2+ and its effectors in vertebrate oocyte maturation ...
Ponnappan, Subramaniam, Hodeify, Rawad, Lu Sun, Amanda Charlesworth, Sun, Lu, Khaled Machaca, Subramaniam Ponnappan, Ponnappan, Usha, Usha Ponnappan, Macnicol, Angus M, Machaca, Khaled, Rawad Hodeify, Claude Prigent, Prigent, Claude, Haun, Shirley, Angus M. MacNicol, Charlesworth, Amanda, Shirley Haun   +17 more
core   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Utero-placental calcium and magnesium ion channels: A systematic review of obstetric implications of their alterations

Channels
Despite the established roles of calcium (Ca2+) and magnesium (Mg2+) in placental function and uterine contractility, limited information exists on how dysregulation of major ion channels contributes to poor pregnancy outcomes. We synthesized data on the
Gaudence Ndinganire, Aime Patrick Niyomugabo, Daniel Udofia Owu, Makinde Vincent Olubiyi, David Chibuike Ikwuka, Alphonse Niyodusenga, Mayowa Jeremiah Adeniyi, Muluken Walle, Onyinye Cynthia Okeke, Abdul-Rahuf Aderemi Feyitimi, Ejike Daniel Eze, Akaninyene Ubong Ime, Elemi John Ani, Abdulazeez Jimoh, Abdullahi Hussein Umar, Diresebachew Wondimu Haile, Abdullateef Isiaka Alagbonsi, Olufunke Onaadepo   +17 more
doaj   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source