Results 101 to 110 of about 202,389 (291)

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Physiology and pathology of calcium signaling in the brain

Frontiers in Pharmacology, 2012
Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene expression, energy production, membrane excitability, synaptogenesis, synaptic ...
Elisa Mitikp Kawamoto, Carmen eVivar, Simonetta eCamandola   +2 more
doaj   +1 more source

Can Endocrine disrupters interfere with Ca2+ homeostasis in invertebrate cells? [PDF]

, 2010
A wide range of environmental chemicals have been shown to alter the endocrine system of both wildlife and humans. There is increasing evidence that many of these endocrine disruptors (EDs), in particular estrogenic chemicals, can rapidly affect cellular
L. Canesi, Caprì, F., B. Marchi, A. Viarengo, Mancinelli, G., Viarengo, A., R. Fabbri, Canesi, L., G. Mancinelli, Gallo, G., F. Dondero, F. Caprì, Marchi, Barbara, Dondero, F., G. Gallo, Fabbri, R.   +15 more
core   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

TMBIM-mediated Ca2+ homeostasis and cell death

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017
Ca2+ is a ubiquitous intracellular messenger that regulates numerous physiological activities in humans, animals, plants, and bacteria. Cytosolic Ca2+ is kept at a low level, but subcellular organelles such as the endoplasmic reticulum (ER) and Golgi apparatus maintain high-concentration Ca2+ stores.
openaire   +2 more sources

Mitochondrial respiration and Ca2+ waves are linked during fertilization and meiosis completion [PDF]

, 2003
Fertilization increases both cytosolic Ca(2+) concentration and oxygen consumption in the egg but the relationship between these two phenomena remains largely obscure.
Smith, Peter J., Cibert, Christian, Porterfield, Marshall, Rouviere, Christian, Sardet, Christian, Hammar, Katherine, Porterfield, D. Marshall, Smith, Peter J. S., Dumollard, Remi, Hammar, Katherine M.   +9 more
core   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux [PDF]

, 2017
Ca2+ transport across the inner membrane of mitochondria (IMM) is of major importance for their functions in bioenergetics, cell death and signaling. It is therefore tightly regulated.
Zoratti, Mario, Diego De Stefani, Mattarei, Andrea, Julia Seifert, Nowikovsky, Karin, Seifert, Julia, Pfeiffer, Christina, Austin, Shane, Andrea Mattarei, De Stefani, Diego, Tavakoli, Mojtaba, Mario Zoratti, Christina Pfeiffer, Shane Austin, Mojtaba Tavakoli, Karin Nowikovsky   +15 more
core   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Highly dynamic and sensitive NEMOer calcium indicators for imaging ER calcium signals in excitable cells

Nature Communications
The Endoplasmic/sarcoplasmic reticulum (ER/SR) is central to calcium (Ca2+) signaling, yet current genetically encoded Ca2+ indicators (GECIs) cannot detect elementary Ca2+ release events from ER/SR, particularly in muscle cells.
Wenjia Gu, Jia-Hui Chen, Yiyin Zhang, Zhirong Wang, Jia Li, Sijia Wang, Hanhan Zhang, Amin Jiang, Ziyi Zhong, Jiaxuan Zhang, Ze Xu, Panpan Liu, Chao Xi, Tingting Hou, Donald L. Gill, Dong Li, Yu Mu, Shi-Qiang Wang, Ai-Hui Tang, Youjun Wang   +19 more
doaj   +1 more source