Results 31 to 40 of about 110,913 (348)
Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]
, 2019 Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S. +9 more
core +1 more source
Kidney function in cachexia and sarcopenia: Facts and numbers
Journal of Cachexia, Sarcopenia and Muscle, 2023 Cachexia, in the form of unintentional weight loss >5% in 12 months or less, and secondary sarcopenia in the form of muscle wasting are serious conditions that affect clinical outcomes.
Masatsugu Okamura +5 more
semanticscholar +1 more source
Physiological Reports, 2020 Skeletal muscle atrophy is common across a variety of pathologies. Underlying mechanisms of atrophy differ between pathologies, and in many conditions, circulating factors are tied to muscle atrophy.
Seongkyun Lim +6 more
doaj +1 more source
European Heart Journal Supplements, 2019 AbstractCachexia is a multifactorial disease characterized by a pathologic shift of metabolism towards a more catabolic state. It frequently occurs in patients with chronic diseases such as chronic heart failure and is especially common in the elderly. In patients at risk, cardiac cachexia is found in about 10% of heart failure patients.
Lena, Alessia +2 more
openaire +3 more sources
Journal of Cachexia, Sarcopenia and Muscle, 2023 In cancer cachexia trials, measures of physical function are commonly used as endpoints. For drug trials to obtain regulatory approval, efficacy in physical function endpoints may be needed alongside other measures.
James McDonald +28 more
semanticscholar +1 more source
International Journal of Cell Biology, 2012 Cytochrome c is a key molecule in mitochondria-mediated apoptosis. It also plays a pivotal role in cell respiration. The switch between these two functions occurs at the moment of its release from mitochondria.
Libera Berghella, Elisabetta Ferraro
doaj +1 more source
Mediators and clinical treatment for cancer cachexia: a systematic review
JCSM Rapid Communications, 2021 Background Cachexia, a complex multi‐organ syndrome, shortens survival time of patients, particularly those with cancer. Many studies and clinical trials have been carried out to identify cachexia‐inducing factors and potential treatments for cancer ...
Zhipeng Cao +3 more
doaj +1 more source
Cancer Cachexia: Its Mechanism and Clinical Significance
International Journal of Molecular Sciences, 2021 The term “cachexia” is derived from the Greek words kakos (bad) and hexis (habit). Cachexia is a malnutrition associated with chronic diseases such as cancer, chronic heart failure, chronic renal failure, and autoimmune diseases, and is characterized by ...
H. Nishikawa +5 more
semanticscholar +1 more source
A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]
, 2015 Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W. +2 more
core +1 more source
Journal of Oral and Maxillofacial Pathology, 2011 Cancer cachexia is a wasting syndrome characterized by weight loss, anorexia, asthenia and anemia. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The signs and symptoms of cachexia are considered as the prognostic parameters in cancer patients.
Dhanapal, Raghu +2 more
openaire +3 more sources