Results 41 to 50 of about 110,913 (348)

The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia

International Journal of Molecular Sciences, 2021
Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic activity, and systemic inflammation.
A. Kasprzak
semanticscholar   +1 more source

Circulating monocyte chemoattractant protein‐1 (MCP‐1) is associated with cachexia in treatment‐naïve pancreatic cancer patients

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Cancer‐associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose.
Erin E. Talbert, Heather L. Lewis, Matthew R. Farren, Mitchell L. Ramsey, Jeffery M. Chakedis, Priyani Rajasekera, Ericka Haverick, Angela Sarna, Mark Bloomston, Timothy M. Pawlik, Teresa A. Zimmers, Gregory B. Lesinski, Phil A. Hart, Mary E. Dillhoff, Carl R. Schmidt, Denis C. Guttridge   +15 more
doaj   +1 more source

The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer [PDF]

, 2018
Low muscle mass in individuals with cancer has a profound impact on quality of life and independence and is associated with greater treatment toxicity and poorer prognosis.
Fairman, C M, Galvao, D A, Hart, Nicolas H, Kendall, K L, Newton, R U, Taaffe, D R   +5 more
core   +2 more sources

Cancer cachexia: a nutritional or a systemic inflammatory syndrome?

British Journal of Cancer, 2022
Cancer cachexia has long been perceived as a nutritional syndrome. However, nutritional interventions have continued to be ineffective. With the recent recognition of the importance of systemic inflammation in the definition of this syndrome and ...
J. McGovern, R. Dolan, R. Skipworth, B. Laird, D. McMillan   +4 more
semanticscholar   +1 more source

Implications of skeletal muscle loss for public health nutrition messages:a brief report [PDF]

, 2015
Age-related skeletal muscle loss, sarcopenia, cachexia and wider malnutrition (under nutrition) are complex in aetiology with interaction of clinical, social and economic factors.
Levy, Louis B, Welch, Ailsa A
core   +1 more source

Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function [PDF]

, 2018
Muscle wasting in cancer negatively affects physical function and quality of life. This study investigates amino acid metabolism and the association with muscle mass and function in patients with cancer.In 16 patients with advanced cancer undergoing ...
Deutz, Nicolaas E P, Engelen, Marielle P., Rodriguez, Ramon E., Van der Meij, Barbara S   +3 more
core   +1 more source

Cardiac cachexia

Annals of Medicine, 2004
Chronic heart failure (CHF) remains an important and increasing public health care problem. It is a complex syndrome affecting many body systems. Body wasting (i.e., cardiac cachexia) has long been recognised as a serious complication of CHF. Cardiac cachexia is associated with poor prognosis, independently of functional disease severity, age, and ...
Stefan D, Anker, Wolfram, Steinborn, Sabine, Strassburg   +2 more
openaire   +2 more sources

Targeting cancer cachexia: Molecular mechanisms and clinical study

MedComm, 2022
Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer cachexia environment. During the occurrence and progression of cancer cachexia,
Yong‐Fei Wang, Zi‐Yi An, Dong‐Hai Lin, Wei‐Lin Jin   +3 more
doaj   +1 more source

Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]

, 2018
The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B., Hodgson, Joseph A., Parvy, Jean-Philippe   +2 more
core   +3 more sources

Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia

Journal of Experimental Medicine, 2021
Cachexia increases morbidity and mortality. Rupert et al. show PDAC cachexia results from tissue crosstalk via an IL-6 trans-signaling loop. Malignant cells signal via IL-6 to muscle and fat, muscle to fat via sIL6R, and fat to muscle via lipids and IL-6.
Joseph E. Rupert, Ashok Narasimhan, D. Jengelley, Yanlin Jiang, Jianguo Liu, Ernie Au, L. Silverman, G. Sandusky, A. Bonetto, Sha Cao, Xiaoyu Lu, T. O’Connell, Yunlong Liu, L. Koniaris, T. Zimmers   +14 more
semanticscholar   +1 more source