Results 81 to 90 of about 110,913 (348)

Signaling networks governing skeletal muscle growth, atrophy, and cachexia

Skeletal Muscle
Maintaining skeletal muscle mass and strength is essential for healthy aging and overall longevity. Muscle mass is governed by a complex network of signaling pathways that coordinate proteostasis and regulate the expression of anabolic and catabolic ...
Aniket S Joshi, Meiricris Tomaz da Silva, Savita Kumar, Ashok Kumar   +3 more
doaj   +1 more source

Inflammation in Cachexia

Mediators of Inflammation, 2015
Cachexia is a complex wasting syndrome associated with a marked detrimental effect upon life quality and survival in patients with cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure, AIDS, and chronic kidney disease, among other conditions. Its prevalence is of around 5 to 15% in cardiac patients at end stage, rising up to 30%,
Seelaender M., Busquets S., Laviano A., Püschel G., Margaria T., Batista M. L. Jr.   +5 more
openaire   +5 more sources

Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC‐1 study design

Journal of Cachexia, Sarcopenia and Muscle
Cancer cachexia is a multifactorial metabolic wasting syndrome characterized by anorexia, unintentional loss of weight involving both skeletal muscle and adipose tissues, progressive functional impairment and reduced survival.
John D. Groarke, Jeffrey Crawford, Susie M Collins, Shannon L Lubaczewski, Danna M. Breen, Magdalena A Harrington, I. Jacobs, Ruolun Qiu, James H Revkin, M. Rossulek, Aditi R. Saxena   +10 more
semanticscholar   +1 more source

Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia

Experimental and Molecular Medicine, 2022
Cancer cachexia syndrome is a major cause of morbidity and mortality in cancer patients in the advanced stage. It is a devastating disorder characterized by nutritional impairment, weakness, and wasting, and it affects treatment success and quality of ...
E. Yeom, Kweon Yu
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancer [PDF]

, 2010
<b>Background & aims:</b> The involvement of a systemic inflammatory response, as evidenced by the Glasgow Prognostic Score (GPS), is associated with weight loss and poor outcome in patients with non-small cell lung cancer.
Forrest, L.M., McMillan, D.C., Meek, C.L., Wallace, A.M.   +3 more
core   +1 more source

Inflammation and Skeletal Muscle Wasting During Cachexia

Frontiers in Physiology, 2020
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality and treatment efficacy in patients with cancer or chronic inflammatory disease.
Justine M. Webster, Laura J. A. P. Kempen, R. Hardy, R. Langen   +3 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The impact of pulmonary cachexia on inpatient outcomes: A national study

Annals of Thoracic Medicine, 2023
BACKGROUND: Cachexia has been associated with chronic lung disease (pulmonary cachexia syndrome), which is associated with increased mortality. However, studies that looked into this association was relatively small, and national level data are lacking ...
Mohamad Alhoda Mohamad Alahmad, Cheryl A Gibson   +1 more
doaj   +1 more source

How and why systemic inflammation worsens quality of life in patients with advanced cancer [PDF]

, 2017
Introduction: The presence of an innate host systemic inflammatory response has been reported to be a negative prognostic factor in a wide group of solid tumour types in both the operable and advanced setting, both local and distant.
Dolan, Ross D., Horgan, Paul G., McMillan, Donald C., McSorley, Stephen T., Roxburgh, Campbell S.D.   +4 more
core   +1 more source