Results 191 to 200 of about 26,522 (261)

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Calcium and Ca²⁺-Binding Proteins Regulate Microtubule and Cytoskeletal Dynamics During Mammalian Corticogenesis. [PDF]

Brain Sci
De la Merced-García DS, Valle-Bautista R, Hernández-García R, Díaz NF, Molina-Hernández A.   +4 more
europepmc   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Cdhr1a and pcdh15b may link photoreceptor outer segments with calyceal processes revealing a potential mechanism for cone-rod dystrophy. [PDF]

Elife
Patel MK, Piedade WP, Famulski JK.
europepmc   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Plakoglobin phosphorylation at serine 665 is capable of stabilizing cadherin-mediated adhesion in keratinocytes. [PDF]

JCI Insight
Vielmuth F, Sigmund AM, Egu DT, Hiermaier M, Steinert LS, Moztarzadeh S, Klimkina M, Schikora ME, Rion PM, Schmitt T, Meier K, Ghoreschi K, Horn AK, Radeva MY, Kugelmann D, Waschke J.   +15 more
europepmc   +1 more source

Bilateral Prophylactic and Contralateral Risk‐Reducing Mastectomy in Women With Germline CDH1 Pathogenic or Likely‐Pathogenic Variants

Journal of Surgical Oncology, EarlyView.
ABSTRACT Bilateral prophylactic mastectomy (BPM) or contralateral risk‐reducing mastectomy (CRRM) are considered in CDH1 carriers as a strategy to reduce lobular breast cancer (LBC) risk in women. In this study we aimed to evaluate the overall number of these procedures reported in literature.
Giovanni Corso, Carlo La Vecchia, Francesca Magnoni, Andrea Polizzi, Elisa Bottazzoli, Alessandra De Scalzi, Susanna Di Silvestre, Eleonora Meduri, Filippo Pesapane, Luca Nicosia, Francesca De Lorenzi, Mattia Intra, Viviana Galimberti, Paolo Veronesi   +13 more
wiley   +1 more source

A Quantitative Sorting Score for High-Throughput Analysis of Cell Organization in Spheroids

Park J, Schulten A, Wegner SV.
europepmc   +1 more source

Soluble T-Cadherin: A Novel Biomarker for Fluid Resuscitation in Burn Patients-A Single-Center Retrospective Observational Study. [PDF]

Shock
Yoneda K, Ebihara T, Fukuda S, Kita S, Onishi S, Matsuura H, Osuka A, Nishizawa H, Shimomura I, Oda J.   +9 more
europepmc   +1 more source

KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley   +1 more source