Results 221 to 230 of about 65,722 (350)

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets. [PDF]

MedComm (2020)
Long Y, Wang P, Lei J, Su B, Wei Q, Liu X.   +5 more
europepmc   +1 more source

Cadherin-11 in Renal Cell Carcinoma Bone Metastasis

, 2014
Robert L. Satcher, Tianhong Pan, Chien-Jui Cheng, Yu-Chen Lee, Song-Chang Lin, Guoyu Yu, Xiaoxia Li, Anh Hoang, Pheroze Tamboli, Eric Jonasch, Gary E. Gallick, Sue-Hwa Lin, Sue-Hwa Lin, Sue-Hwa Lin   +13 more
openalex   +2 more sources

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

The Reciprocal Relationship Between Cell Adhesion Molecules and Reactive Oxygen Species. [PDF]

Cells
Al-Hadi M, Nikonenko AG, Sytnyk V.
europepmc   +1 more source

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source

Synthetic mechanoreceptor engineering: From genetic encoding to DNA nanotechnology-based reprogramming. [PDF]

Mechanobiol Med
Yang S, Nie Z.
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

High-pressure freezing of mechanically stretched cells. [PDF]

J Microsc
Felder E, Rüth JL, Abu-Omar B, Wohlwend M, Walther P, Read C.   +5 more
europepmc   +1 more source

Cleavage of E-Cadherin Contributes to Defective Barrier Function in Neosquamous Epithelium

, 2020
Thomas M. Runge, Nicholas J. Shaheen, Zorka Djukic, Suzanne Hallquist, Roy C. Orlando   +4 more
openalex   +1 more source