Immunoglobulin domains in Escherichia coli and other enterobacteria: from pathogenesis to applications in antibody technologies [PDF]
, 2012 The immunoglobulin (Ig) protein domain is widespread in nature having a well-recognized role in proteins of the immune system. In this review, we describe the proteins containing Ig-like domains in Escherichia coli and entero-bacteria, reporting their ...
Bluhm, Hendrik +3 more
core +2 more sources
Engineering Lipid Nanoparticles for mRNA Immunotherapy
WIREs Nanomedicine and Nanobiotechnology, Volume 17, Issue 2, March/April 2025.ABSTRACT Over the last decades, messenger RNA (mRNA) has emerged as a promising therapeutic modality, enabling the delivery of genetic instructions to cells for producing therapeutic proteins or antigens. As such, mRNA‐based therapies can be developed for a wide range of conditions, including infections, cancer, metabolic disorders, and genetic ...
Robby Zwolsman +3 more
wiley +1 more source
A vaccine formulated with the major outer membrane protein can protect C3H/HeN, a highly susceptible strain of mice, from a Chlamydia muridarum genital challenge. [PDF]
, 2015 C3H/HeN female mice were vaccinated with native Chlamydia muridarum major outer membrane protein (MOMP), using Montanide+CpG or Alum+CpG as adjuvants. Negative control groups were immunized with ovalbumin (OVA) and the same adjuvants. As positive control,
de la Maza, Luis M +2 more
core +1 more source
The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay. [PDF]
, 2018 The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA levels are determined through its
Begley, Victoria Sarah
core
A rapid and efficient method to purify proteins at replication forks under native conditions
BioTechniques, 2013 Tools for studying replication fork dynamics are critical for dissecting the mechanisms of DNA replication, DNA repair, histone deposition, and epigenetic memory.
Kai Him Thomas Leung +2 more
doaj +1 more source
eLife, 2016 The histone chaperone Chromatin Assembly Factor 1 (CAF-1) deposits tetrameric (H3/H4)2 histones onto newly-synthesized DNA during DNA replication. To understand the mechanism of the tri-subunit CAF-1 complex in this process, we investigated the protein ...
Wallace H Liu +11 more
doaj +1 more source
Engineered Caf1 Protein Polymers form Tuneable Bioactive Hydrogel Scaffolds [PDF]
Biophysical Journal, 2018 Helen Waller +4 more
openaire +1 more source
HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogaster [PDF]
, 2017 Heterochromatin protein 1 (HP1) was originally described as a non-histone chromosomal protein and is required for transcriptional gene silencing and the formation of heterochromatin.
De Lucia, Filomena +3 more
core
Efecto de la administración exógena de IL-12 en un modelo murino de enfermedad de injerto contra el huésped [PDF]
, 2005 Consultable des del TDXTítol obtingut de la portada digitalitzadaHemos analizado el efecto de la IL-12 sobre la enfermedad autoinmune en un modelo murino semialogénico de enfermedad crónica de injerto contra el huésped (EICHc) inducida en ratones (Balb/c
Gallego Valadés, Francisca
core +3 more sources
Evolution of genes and genomes on the Drosophila phylogeny [PDF]
, 2007 Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide.
Clark, Andrew G., Pachter, Lior
core