Results 101 to 110 of about 6,761 (193)
Harnessing the Potential of mRNA Vaccines Against Infectious Diseases
Microbial Biotechnology, Volume 18, Issue 8, August 2025.RNA vaccines are promising because of their flexible design, strong immunogenicity, safety and rapid development. Recent advances have enabled mRNA vaccines to target various pathogens, including viruses such as influenza and HIV, bacteria such as Mycobacteria and Pseudomonas aeruginosa, and parasites such as those causing malaria.
Nouran Rezk, Siobhán McClean
wiley +1 more source
Evaluation of immunohistochemical expression of ghrelin-producing rectal cells in Wistar rats underwent to the cafeteria diet [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE:To investigate the impact of cafeteria diet on ghrelin expression in rectal tissue and identify the morphologic cell type. METHODS:Twenty-four male Wistar rats were divided into four subgroups of six animals each: RC1 (rat chow 1) and CAF1 ...
Humberto Fenner Lyra Junior +7 more
doaj +1 more source
A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila [PDF]
The EMBO Journal, 2004 The CCR4-NOT complex is the major enzyme catalyzing mRNA deadenylation in Saccharomyces cerevisiae. We have identified homologs for almost all subunits of this complex in the Drosophila genome. Biochemical fractionation showed that the two likely catalytic subunits, CCR4 and CAF1, were associated with each other and with a poly(A)-specific 3 ...
Claudia, Temme +4 more
openaire +2 more sources
EBV Latency Programs: Molecular and Epigenetic Regulation and Its Role in Disease Pathogenesis
Journal of Medical Virology, Volume 97, Issue 7, July 2025.ABSTRACT Epstein‐Barr virus (EBV) asymptomatically infects over 95% of the global population, and poses a great threat to human health. This review summarizes the complex mechanisms underlying EBV latency programs and their roles in both viral persistence and disease development.
Likang Lyu, Qian Li, Chong Wang
wiley +1 more source
Establishment of a promoter based chromatin architecture on recently replicated DNA can accommodate variable internucleosome spacing [PDF]
, 2016 Nucleosomes, the fundamental subunits of eukaryotic chromatin, are organized with respect to transcriptional start sites. A major challenge to the persistence of this organization is the disassembly of nucleosomes during DNA replication.
Fennessy, Ross T., Owen-Hughes, Thomas
core +2 more sources
Molecular subtyping and precision therapy for esophageal cancer
Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei +5 more
wiley +1 more source
Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells [PDF]
, 2016 Cancer associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus predominantly on targeting the proliferation of rapidly growing cancer epithelial cells ...
Fishel, Melissa L. +5 more
core +2 more sources
Journal of Extracellular Biology, Volume 4, Issue 3, March 2025.ABSTRACT Several reports have demonstrated that CD147, an N‐glycosylated protein that is exchanged by cells in soluble form or through small extracellular vesicles (sEVs), can promote cancer progression. However, its activity related to EVs in colorectal cancer (CRC) is still not fully understood.
Filomena Colella +15 more
wiley +1 more source
Synthesis and expression of caf1 gene encoding F1 antigen of Yersinia pestis
Vietnam Journal of Biotechnology, 2016 Yersinia pestis is the etiologic agent of plague, one of the most deadly infectious diseases described in the history of humanity. It was responsible for millions of deaths all over the world. Yersinia pestis also can be used as a highly lethal biological potential weapon. For plague diagnosis in humans as well as to detect Y. pestis in the environment,
Nguyễn Thị Thu Hà +4 more
openaire +2 more sources
FEBS Letters, 2019 TAR DNA‐binding protein 43 (TDP‐43) is an RNA‐binding protein, whose loss‐of‐function mutation causes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. Recent studies demonstrated that TDP‐43 binds to the 3′ untranslated region (UTR) of target mRNAs to promote mRNA instability.
Makoto, Fukushima +3 more
openaire +3 more sources