Results 81 to 90 of about 6,761 (193)
Complex RNA metabolism in the chloroplast: an update on the psbB operon [PDF]
, 2012 Expression of most plastid genes involves multiple post-transcriptional processing events, such as splicing, editing, and intercistronic processing. The latter involves the formation of mono-, di-, and multicistronic transcripts, which can further be ...
Jörg Meurer, Rhea Stoppel
core +1 more source
Cell Proliferation, Volume 59, Issue 1, January 2026.Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen +4 more
wiley +1 more source
The biological function of the WD40 repeat‐containing protein p55/Caf1 in Drosophila [PDF]
Developmental Dynamics, 2012 AbstractBackground: The p55 family WD40 repeat‐containing histone chaperone proteins are components of several chromatin regulatory complexes (such as PRC2, NURF and CAF‐1) and interact with histone H4, yet their functional relevance in vivo is unclear.
Pei, Wen, Zhenghui, Quan, Rongwen, Xi
openaire +2 more sources
Transcription and FACT facilitate the restoration of replication-coupled chromatin assembly defects
Scientific Reports, 2023 Genome duplication occurs through the coordinated action of DNA replication and nucleosome assembly at replication forks. Defective nucleosome assembly causes DNA lesions by fork breakage that need to be repaired.
Marta Barrientos-Moreno +6 more
doaj +1 more source
Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma [PDF]
, 2018 In this study, our aim is to assess the role played by autophagy and its inhibition in the different PDAC cellular compartments, and its involvement in chemo-resistance using primary human pancreatic cancer-derived cells (PCC) and Cancer Associated ...
Bintz, Jennifer +6 more
core +1 more source
BioMed Research International, Volume 2026, Issue 1, 2026.Colorectal cancer (CRC) is highly metastatic, yet the interaction between tumor cells and microenvironment components remains unclear, as does its impact on patient outcomes. Single‐cell data (GSE225857 and GSE166555) were collected for transformed and primary CRC to identify differing cell types and their subpopulations. Prognostic signature genes for
Yiqing Tan +9 more
wiley +1 more source
Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo [PDF]
RNA, 2015 RNA-regulatory factors bound to 3′ UTRs control translation and stability. Repression often is associated with poly(A) removal. The deadenylase CAF1 is a core component of the CCR4–NOT complex. Our prior studies established that CAF1 represses translation independent of deadenylation.
Waghray, Shruti +3 more
openaire +2 more sources
BTG/TOB factors impact deadenylases. [PDF]
, 2009 BTG/TOB factors are a family of antiproliferative proteins whose expression is altered in numerous cancers. They have been implicated in cell differentiation, development and apoptosis.
Chen, Chyi-Ying A +3 more
core +1 more source
MMS22L is a novel key actor of normal and pathological erythropoiesis
HemaSphere, Volume 9, Issue 12, December 2025.Abstract The emergence of next‐generation sequencing techniques has led to the genetic characterization of numerous congenital erythroid disorders, emphasizing crucial pathways in both normal and pathological erythropoiesis. In this study, whole exome sequencing of a single patient with atypical congenital pure red cell aplasia revealed a mutation in ...
Elia Colin +31 more
wiley +1 more source
A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells [PDF]
Nucleic Acids Research, 2008 The eukaryotic Ccr4/Caf1/Not complex is involved in deadenylation of mRNAs. The Caf1 and Ccr4 subunits both potentially have deadenylating enzyme activity. We investigate here the roles of Ccr4 and Caf1 in deadenylation in two organisms that separated early in eukaryotic evolution: humans and trypanosomes.
Schwede, Angela +5 more
openaire +2 more sources