Results 61 to 70 of about 6,761 (193)

Development and evaluation of loop-mediated isothermal amplification for detection of Yersinia pestis in plague biological samples.

open access: yesPLoS ONE, 2020
BACKGROUND:Several tests are available for plague confirmation but bacteriological culture with Yersinia pestis strain isolation remains the gold standard according to the World Health Organization.
Lovasoa N Randriantseheno   +4 more
doaj   +1 more source

CAF-1 is essential for heterochromatin organization in pluripotent embryonic cells. [PDF]

open access: yesPLoS Genetics, 2006
During mammalian development, chromatin dynamics and epigenetic marking are important for genome reprogramming. Recent data suggest an important role for the chromatin assembly machinery in this process. To analyze the role of chromatin assembly factor 1
Martin Houlard   +6 more
doaj   +1 more source

H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development

open access: yesJournal of Cardiovascular Development and Disease, 2023
Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with ...
Jun-yi Zhu   +5 more
doaj   +1 more source

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

open access: yesJournal of Integrative Plant Biology, EarlyView.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung   +5 more
wiley   +1 more source

Biochemical and biophysical characterization of the deadenylase CrCaf1 from Chlamydomonas reinhardtii. [PDF]

open access: yesPLoS ONE, 2013
The modulation of mRNA turnover has been increasingly recognized as a hotpoint for gene expression regulation at the post-transcriptional level. In eukaryotic cells, most mRNAs are degraded via the deadenylation-dependent pathway, in which the removal of
Jia-Quan Zhang   +2 more
doaj   +1 more source

Simultaneous SNP identification in association studies with missing data

open access: yes, 2012
Association testing aims to discover the underlying relationship between genotypes (usually Single Nucleotide Polymorphisms, or SNPs) and phenotypes (attributes, or traits).
Casella, George   +4 more
core   +1 more source

Pentatricopeptide repeat proteins in crops: Advances in functional mechanisms and breeding applications

open access: yesJournal of Integrative Plant Biology, EarlyView.
Pentatricopeptide repeat proteins coordinate nucleus‐organelle communication by modulating RNA metabolism within chloroplasts and mitochondria. This review highlights how they control critical processes like photosynthesis, seed development, fertility restoration, and stress survival in crops, and explores their potential as programmable tools for RNA ...
Mingming Wu   +7 more
wiley   +1 more source

CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4 [PDF]

open access: yesNucleic Acids Research, 2007
The CAF1 protein is a component of the CCR4-NOT deadenylase complex. While yeast CAF1 displays deadenylase activity, this activity is not required for its deadenylation function in vivo, and CCR4 is the primary deadenylase in the complex. In order to identify CAF1-specific functional regions required for deadenylation in vivo, we targeted for ...
Ohn, Takbum   +5 more
openaire   +3 more sources

Ambient stable quantitative PCR reagents for the detection of Yersinia pestis. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2010
BACKGROUND: Although assays for detecting Yersinia pestis using TaqMan probe-based real-time PCR have been developed for years, little is reported on room-temperature-stable PCR reagents, which will be invaluable for field epidemic surveillance ...
Shi Qu   +6 more
doaj   +1 more source

Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex

open access: yesFrontiers in Cell and Developmental Biology, 2023
Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello   +2 more
doaj   +1 more source

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