Results 61 to 70 of about 4,758 (202)
Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction [PDF]
Molecular Cell, 2012 Shortening eukaryotic poly(A) tails represses mRNA translation and induces mRNA turnover. The major cytoplasmic deadenylase, the Ccr4-Not complex, is a conserved multisubunit assembly. Ccr4-Not is organized around Not1, a large scaffold protein that recruits two 3'-5' exoribonucleases, Caf1 and Ccr4.
Basquin, J +5 more
openaire +5 more sources
Functional analysis of the CAF1 protein [PDF]
, 2006 The CAF1 protein is a component of the CCR4-NOT deadenylase complex. While yeast CAF1 displays deadenylase activity, this activity is not required for its function in vivo, and CCR4 is the primary deadenylase in the complex.
Ohn, Takbum
core +1 more source
Leukemia and Lymphoma, 2020 Mutations in the highly similar genes B-cell translocation gene 1 (BTG1) and BTG2 are identified in approximately 10–15% of non-Hodgkin lymphoma cases, which may suggest a direct involvement of BTG1 and BTG2 in malignant transformation.
H. Almasmoum +3 more
semanticscholar +1 more source
CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4 [PDF]
, 2007 The CAF1 protein is a component of the CCR4 - NOT deadenylase complex. While yeast CAF1 displays deadenylase activity, this activity is not required for its deadenylation function in vivo, and CCR4 is the primary deadenylase in the complex.
Chiang, Yueh-Chin +11 more
core +1 more source
, 2023 Additional file 1: Figure S1. Caf1 Binding Motifis a minimal binding site of Caf1. A. A series of the truncation constructs of CBM. Strong binding is indicated with ‘++’, weak binding with ‘+’ and no binding with ‘−’ based on GST-pulldown experiments. B.
Eojin Yoon (13254034) +1 more
core +1 more source
X-linked RBBP7 mutation causes maturation arrest and testicular tumors
The Journal of Clinical Investigation, 2023 Maturation arrest (MA) is a subtype of non-obstructive azoospermia, and male infertility is a known risk factor for testicular tumors. However, the genetic basis for many affected individuals remains unknown.
Jingping Li +7 more
doaj +1 more source
bioRxiv, 2020 Protein degradation by ubiquitin proteasome system (UPS) is the major selective proteolytic pathway responsible for the degradation of short lived proteins ranging from regulatory proteins to abnormal proteins.
Ganapathi Kandasamy +2 more
semanticscholar +1 more source
Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation [PDF]
Molecular Cell, 2009 MicroRNAs (miRNAs) inhibit mRNA expression in general by base pairing to the 3'UTR of target mRNAs and consequently inhibiting translation and/or initiating poly(A) tail deadenylation and mRNA destabilization. Here we examine the mechanism and kinetics of miRNA-mediated deadenylation in mouse Krebs-2 ascites extract.
Fabian, Marc R +16 more
openaire +5 more sources
Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
doaj +1 more source
The biological function of the WD40 repeat‐containing protein p55/Caf1 in Drosophila [PDF]
Developmental Dynamics, 2012 AbstractBackground: The p55 family WD40 repeat‐containing histone chaperone proteins are components of several chromatin regulatory complexes (such as PRC2, NURF and CAF‐1) and interact with histone H4, yet their functional relevance in vivo is unclear.
Pei, Wen, Zhenghui, Quan, Rongwen, Xi
openaire +2 more sources