Results 41 to 50 of about 4,758 (202)
Developing and evaluation of orodispersible tablets containing caffeine [PDF]
Romanian Journal of Pharmaceutical Practice, 2021 Starting from the premise that a reduced number of active pharmaceutical ingredients (APIs) are used to treat hypotension, the aim of this study consisted of developing new formulations of caffeine-orodispersible tablets (CAFODTs).
Robert-Alexandru Vlad +7 more
doaj +1 more source
Investigating the function of CAF1 deadenylases during plant stress responses [PDF]
Plant Signaling & Behavior, 2010 Alteration of gene expression plays a central role in the transmission of developmental and environmental signals. The steady-state transcript level within a cell is determined by the combination of the rate synthesis and the rate of degradation. While altering the rate of mRNA turnover is known to provide a rapid mechanism to reprogram transcript ...
Justin W, Walley +3 more
openaire +2 more sources
Cancers, 2021 Simple Summary Cancer cells generally reprogram their gene expression profiles to satisfy continuous growth, proliferation, and metastasis. Most eukaryotic mRNAs are degraded in a deadenylation-dependent pathway, in which deadenylases are the key enzymes.
Xiao Song +6 more
semanticscholar +1 more source
A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells [PDF]
Nucleic Acids Research, 2008 The eukaryotic Ccr4/Caf1/Not complex is involved in deadenylation of mRNAs. The Caf1 and Ccr4 subunits both potentially have deadenylating enzyme activity. We investigate here the roles of Ccr4 and Caf1 in deadenylation in two organisms that separated early in eukaryotic evolution: humans and trypanosomes.
Schwede, Angela +5 more
openaire +2 more sources
Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin [PDF]
Nucleic Acids Research, 2011 The carbon catabolite repressor protein 4 (Ccr4)-Negative on TATA (Not) complex controls gene expression at two levels. In the nucleus, it regulates the basal transcription machinery, nuclear receptor-mediated transcription and histone modifications. In the cytoplasm, the complex is required for messenger RNA (mRNA) turnover through its two associated ...
Sandler, Heike +3 more
openaire +2 more sources
BMC Microbiology, 2019 Background Thermal regulation of gene expression occurs in many microorganisms, and is mediated via several typical mechanisms. Yersinia pestis is the causative agent of the plague and spreads by zoonotic transfer from fleas to mammalian blood with a ...
Abdulmajeed D. Al-Jawdah +5 more
doaj +1 more source
An Unconventional Human Ccr4-Caf1 Deadenylase Complex in Nuclear Cajal Bodies [PDF]
Molecular and Cellular Biology, 2007 mRNA deadenylation is a key process in the regulation of translation and mRNA turnover. In Saccharomyces cerevisiae, deadenylation is primarily carried out by the Ccr4p and Caf1p/Pop2p subunits of the Ccr4-Not complex, which is conserved in eukaryotes including humans.
Eileen, Wagner +2 more
openaire +2 more sources
eLife, 2017 How the very first step in nucleosome assembly, deposition of histone H3-H4 as tetramers or dimers on DNA, is accomplished remains largely unclear. Here, we report that yeast chromatin assembly factor 1 (CAF1), a conserved histone chaperone complex that ...
Paul Victor Sauer +10 more
doaj +1 more source
Yersinia pestis caf1Variants and the Limits of Plague Vaccine Protection [PDF]
Infection and Immunity, 2008 ABSTRACTYersinia pestis, the highly virulent agent of plague, is a biological weapon. Strategies that prevent plague have been sought for centuries, and immunization with live, attenuated (nonpigmented) strains or subunit vaccines with F1 (Caf1) antigen is considered effective.
Lauriane E, Quenee +4 more
openaire +2 more sources