Results 31 to 40 of about 3,723 (183)
Conservation of the deadenylase activity of proteins of the Caf1 family in human [PDF]
RNA, 2005 The yeast Pop2 protein, belonging to the eukaryotic Caf1 family, is required for mRNA deadenylation in vivo. It also catalyzes poly(A) degradation in vitro, even though this property has been questioned. Caf1 proteins are related to RNase D, a feature supported by the recently published structure of Pop2.
Claire, Bianchin +4 more
openaire +2 more sources
Additional file 1 of Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3 [PDF]
, 2023 Additional file 1: Figure S1. Caf1 Binding Motifis a minimal binding site of Caf1. A. A series of the truncation constructs of CBM. Strong binding is indicated with ‘++’, weak binding with ‘+’ and no binding with ‘−’ based on GST-pulldown experiments. B.
Eojin Yoon (13254034) +1 more
core +1 more source
Investigating the function of CAF1 deadenylases during plant stress responses [PDF]
Plant Signaling & Behavior, 2010 Alteration of gene expression plays a central role in the transmission of developmental and environmental signals. The steady-state transcript level within a cell is determined by the combination of the rate synthesis and the rate of degradation. While altering the rate of mRNA turnover is known to provide a rapid mechanism to reprogram transcript ...
Justin W, Walley +3 more
openaire +2 more sources
Direct Quantification of Protein Antigens in Subunit Plague and Rickettsial Vaccine Preparations
Проблемы особо опасных инфекций, 2023 The aim of the work was to put forward the methods for direct quantitative determination of the content of Yersinia pestis and Rickettsia raoultii protein antigens in preparations and various prototypes of subunit vaccines. Materials and methods.
P. Kh. Kopylov, S. V. Dentovskaya
doaj +1 more source
Developing and evaluation of orodispersible tablets containing caffeine [PDF]
Romanian Journal of Pharmaceutical Practice, 2021 Starting from the premise that a reduced number of active pharmaceutical ingredients (APIs) are used to treat hypotension, the aim of this study consisted of developing new formulations of caffeine-orodispersible tablets (CAFODTs).
Robert-Alexandru Vlad +7 more
doaj +1 more source
A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells [PDF]
Nucleic Acids Research, 2008 The eukaryotic Ccr4/Caf1/Not complex is involved in deadenylation of mRNAs. The Caf1 and Ccr4 subunits both potentially have deadenylating enzyme activity. We investigate here the roles of Ccr4 and Caf1 in deadenylation in two organisms that separated early in eukaryotic evolution: humans and trypanosomes.
Schwede, Angela +5 more
openaire +2 more sources
eLife, 2017 How the very first step in nucleosome assembly, deposition of histone H3-H4 as tetramers or dimers on DNA, is accomplished remains largely unclear. Here, we report that yeast chromatin assembly factor 1 (CAF1), a conserved histone chaperone complex that ...
Paul Victor Sauer +10 more
doaj +1 more source
An Unconventional Human Ccr4-Caf1 Deadenylase Complex in Nuclear Cajal Bodies [PDF]
Molecular and Cellular Biology, 2007 mRNA deadenylation is a key process in the regulation of translation and mRNA turnover. In Saccharomyces cerevisiae, deadenylation is primarily carried out by the Ccr4p and Caf1p/Pop2p subunits of the Ccr4-Not complex, which is conserved in eukaryotes including humans.
Eileen, Wagner +2 more
openaire +2 more sources
BMC Microbiology, 2019 Background Thermal regulation of gene expression occurs in many microorganisms, and is mediated via several typical mechanisms. Yersinia pestis is the causative agent of the plague and spreads by zoonotic transfer from fleas to mammalian blood with a ...
Abdulmajeed D. Al-Jawdah +5 more
doaj +1 more source
Plants, 2021 Poplar is one of the most widely used tree in afforestation projects. However, it is susceptible to abiotic and biotic stress. CCR4-associated factor 1 (CAF1) is a major member of CCR4-NOT, and it is mainly involved in transcriptional regulation and mRNA
Pu Wang +7 more
doaj +1 more source