Yersinia pestis caf1Variants and the Limits of Plague Vaccine Protection [PDF]
Infection and Immunity, 2008 ABSTRACTYersinia pestis, the highly virulent agent of plague, is a biological weapon. Strategies that prevent plague have been sought for centuries, and immunization with live, attenuated (nonpigmented) strains or subunit vaccines with F1 (Caf1) antigen is considered effective.
Lauriane E, Quenee +4 more
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BMC Microbiology, 2019 Background Thermal regulation of gene expression occurs in many microorganisms, and is mediated via several typical mechanisms. Yersinia pestis is the causative agent of the plague and spreads by zoonotic transfer from fleas to mammalian blood with a ...
Abdulmajeed D. Al-Jawdah +5 more
doaj +1 more source
Molecular Plant-Microbe Interactions, 2014 To decipher the mechanism of pathogenicity in Sclerotinia sclerotiorum, a pathogenicity-defective mutant, Sunf-MT6, was isolated from a T-DNA insertional library.
Xueqiong Xiao +6 more
doaj +1 more source
Halofuginone Disrupted Collagen Deposition via mTOR-eIF2α-ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer. [PDF]
Adv Sci (Weinh)COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Li W +8 more
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SPT5 affects the rate of mRNA degradation and physically interacts with CCR4 but does not control mRNA deadenylation [PDF]
, 2011 The CCR4-NOT complex has been shown to have multiple roles in mRNA metabolism, including that of transcriptional elongation, mRNA transport, and nuclear exosome function, but the primary function of CCR4 and CAF1 is in the deadenylation and degradation ...
Chiang, Yueh-Chin +4 more
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Unraveling the molecular determinants of the anti-phagocytic protein cloak of plague bacteria.
PLoS Pathogens, 2022 The pathogenic bacterium Yersina pestis is protected from macrophage engulfment by a capsule like antigen, F1, formed of long polymers of the monomer protein, Caf1.
Daniel T Peters +7 more
doaj +1 more source
Identification of ebs1, lsm6 and nup159 as suppressors of spt10 effects at ADH2 in Saccharomyces cerevisiae suggests post-transcriptional defects affect mRNA synthesis [PDF]
, 2012 Suppression of the effects of an spt10 mutation on ADH2 expression is a phenotype shared by a small number of genes whose protein products are either components of the CCR4-NOT complex required for mRNA deadenylation and degradation (CCR4, CAF1, NOT4) or
Anderson, Bradley +2 more
core +3 more sources
Thermal stability and rheological properties of the ‘non-stick’ Caf1 biomaterial
Biomedical Materials, 2017 The ability to culture cells in three-dimensions has many applications, from drug discovery to wound healing. 3D cell culture methods often require appropriate scaffolds that mimic the cellular environments of different tissue types. The choice of material from which these scaffolds are made is of paramount importance, as its properties will define the
Ulusu Y +6 more
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Anti‐proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase [PDF]
The EMBO Journal, 2011 Tob is a member of the anti-proliferative protein family, which functions in transcription and mRNA decay. We have previously demonstrated that Tob is involved in the general mechanism of mRNA decay by mediating mRNA deadenylation through interaction with Caf1 and a general RNA-binding protein, PABPC1.
Nao, Hosoda +8 more
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Formation routes and structural details of the CaF1 layer on Si(111) from high-resolution noncontact atomic force microscopy data [PDF]
, 2018 We investigate the CaF1/Si(111) interface using a combination of high-resolution scanning tunnelling and noncontact atomic force microscopy operated at cryogenic temperature as well as x-ray photoelectron spectroscopy.
Moriarty, Philip J. +3 more
core +2 more sources