The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4–Not nuclease module [PDF]
Biochemical Journal, 2015 In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is the Ccr4–Not deadenylase complex, which can be recruited to its target mRNA by RNA-binding proteins or the miRNA repression complex.
Maryati, Marayti +2 more
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Histone Loaders CAF1 and HIRA Restrict Epstein-Barr Virus B-Cell Lytic Reactivation
mBio, 2020 Epstein-Barr virus (EBV) infects 95% of adults worldwide and causes infectious mononucleosis. EBV is associated with endemic Burkitt lymphoma, Hodgkin lymphoma, posttransplant lymphomas, nasopharyngeal and gastric carcinomas. In these cancers and in most
Yuchen Zhang +7 more
doaj +3 more sources
The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs [PDF]
Open Biology, 2016 Once every menstrual cycle, eggs are ovulated into the oviduct where they await fertilization. The ovulated eggs are arrested in metaphase of the second meiotic division, and only complete meiosis upon fertilization. It is crucial that the maintenance of
Michał Pasternak +3 more
doaj +5 more sources
Insight into Interface Engineering at TiO2/Dye through Molecularly Functionalized Caf1 Biopolymer [PDF]
ACS Sustainable Chemistry & Engineering, 2017 The fast charge recombination kinetics and poor sensitizing ability in dye-sensitized solar cells (DSSCs) result in a significant electron loss and performance degradation. However, the retarding of electron recombination and/or increasing light-harvesting efficiency (LHE) via employing an appropriate interface modifier in DSSCs has rarely been ...
Seckin Akin +4 more
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The CCR4 and CAF1 Proteins of the CCR4-NOT Complex Are Physically and Functionally Separated from NOT2, NOT4, and NOT5 [PDF]
Molecular and Cellular Biology, 1999 The CCR4-NOT complex (1 mDa in size), consisting of the proteins CCR4, CAF1, and NOT1 to NOT5, regulates gene expression both positively and negatively and is distinct from other large transcriptional complexes in Saccharomyces cerevisiae such as SNF/SWI, TFIID, SAGA, and RNA polymerase II holoenzyme.
Bai, Yongli +5 more
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Synthesis and expression of caf1 gene encoding F1 antigen of Yersinia pestis [PDF]
Vietnam Journal of Biotechnology, 2016 Yersinia pestis is the etiologic agent of plague, one of the most deadly infectious diseases described in the history of humanity. It was responsible for millions of deaths all over the world. Yersinia pestis also can be used as a highly lethal biological potential weapon. For plague diagnosis in humans as well as to detect Y. pestis in the environment,
Nguyễn Thị Thu Hà +4 more
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DREF Genetically Counteracts Mi-2 and Caf1 to Regulate Adult Stem Cell Maintenance.
PLoS Genetics, 2019 Active adult stem cells maintain a bipotential state with progeny able to either self-renew or initiate differentiation depending on extrinsic signals from the surrounding microenvironment.
Benjamin Angulo +5 more
doaj +3 more sources
1-Hydroxy-xanthine Inhibitors of Caf1 Deadenylase as a Potential Treatment for Osteoporosis [PDF]
, 2019 Caf1 is a subunit of the CCR4-NOT complex. The role of Caf1 is that of a magnesium dependent deadenylase enzyme, which removes the poly(A) tail of mRNA (deadenylation). The degradation of the poly(A) tail has a downstream effect on mRNA translation and subsequent protein synthesis. Caf1 is implicated in several biological processes, an important one of
Ziemann, Max
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Mechanical stability of Caf1 mutants. [PDF]
, 2022 (a) Close up view of a self-complemented Caf1 (cpCaf1) monomer. The gene encoding this monomer was inserted in the middle of 4x I91 protein domains from titin to produce the I912-cpCaf1-I912 construct.
Daniel T. Peters (4345414) +7 more
core +1 more source
CCR4-Associated Factor CAF1 Is an Essential Factor for Spermatogenesis [PDF]
Molecular and Cellular Biology, 2004 The CCR4-associated protein CAF1 has been demonstrated to play several roles in the control of transcription and of mRNA decay. To gain further insight into its physiological function, we generated CAF1-deficient mice. They are viable, healthy, and normal in appearance; however, mCAF1(-/-) male mice are sterile.
Rouault, Jean-Pierre +8 more
openaire +4 more sources