Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease [PDF]
MoleculesThe Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribute a
Ishwinder Kaur +2 more
exaly +4 more sources
Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening [PDF]
BiomoleculesThe human Ccr4–Not complex is a central regulator of post-transcriptional gene regulation, impacting on translation and mRNA degradation. In mRNA degradation, Ccr4–Not participates in the shortening of the mRNA poly(A)-tail via two catalytic subunits ...
Ishwinder Kaur +3 more
doaj +2 more sources
X-linked RBBP7 mutation causes maturation arrest and testicular tumors [PDF]
The Journal of Clinical Investigation, 2023 Maturation arrest (MA) is a subtype of non-obstructive azoospermia, and male infertility is a known risk factor for testicular tumors. However, the genetic basis for many affected individuals remains unknown.
Jingping Li +7 more
doaj +2 more sources
BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
Nature Communications, 2016 BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 ...
Bertrand Séraphin, Fabienne Mauxion
exaly +2 more sources
Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar. [PDF]
PLoS Neglected Tropical DiseasesBackgroundThe plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and timely intervention.
Beza Ramasindrazana +12 more
doaj +2 more sources
Caffeine improves the shooting performance and reaction time of first-person shooter esports players: a dose-response study [PDF]
Frontiers in Sports and Active LivingCaffeine is recognized as one of the most effective dietary ergogenic aids in sports, yet its evidence-based effectiveness in esports is unclear. This study investigated the effects of two different doses of caffeine on the shooting performance and ...
Ethan J. Rogers +5 more
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Yersinia pestis Caf1 Protein: Effect of Sequence Polymorphism on Intrinsic Disorder Propensity, Serological Cross-Reactivity and Cross-Protectivity of Isoforms. [PDF]
PLoS ONE, 2016 Yersinia pestis Caf1 is a multifunctional protein responsible for antiphagocytic activity and is a key protective antigen. It is generally conserved between globally distributed Y. pestis strains, but Y. pestis subsp.
Pavel Kh Kopylov +9 more
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Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3
Epigenetics & Chromatin, 2023 Histone modifications are one of the many key mechanisms that regulate gene expression. Ash1 is a histone H3K36 methyltransferase and is involved in gene activation. Ash1 forms a large complex with Mrg15 and Caf1/p55/Nurf55/RbAp48 (AMC complex). The Ash1
Eojin Yoon, Ji-Joon Song
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Stoichiometry and Change of the mRNA Closed-Loop Factors as Translating Ribosomes Transit from Initiation to Elongation [PDF]
, 2016 Protein synthesis is a highly efficient process and is under exacting control. Yet, the actual abundance of translation factors present in translating complexes and how these abundances change during the transit of a ribosome across an mRNA remains ...
Chiang, Yueh-Chin +6 more
core +11 more sources
Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forks. [PDF]
PLoS Genetics, 2011 Chromatin assembly mutants accumulate recombinogenic DNA damage and are sensitive to genotoxic agents. Here we have analyzed why impairment of the H3K56 acetylation-dependent CAF1 and Rtt106 chromatin assembly pathways, which have redundant roles in H3 ...
Marta Clemente-Ruiz +2 more
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