Results 1 to 10 of about 3,156 (129)

Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease [PDF]

Molecules
The Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribute a
Ishwinder Kaur, Gopal P Jadhav, Peter M Fischer   +2 more
exaly   +4 more sources

Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening [PDF]

Biomolecules
The human Ccr4–Not complex is a central regulator of post-transcriptional gene regulation, impacting on translation and mRNA degradation. In mRNA degradation, Ccr4–Not participates in the shortening of the mRNA poly(A)-tail via two catalytic subunits ...
Ishwinder Kaur, Lubna Hashmi, Peter M. Fischer, Gerlof Sebastiaan Winkler   +3 more
doaj   +2 more sources

Establishment and application of a quadruple target real-time PCR assay for detecting Yersinia pestis. [PDF]

PLoS ONE
In order to establish an efficient method for high-throughput detection of Yersinia pestis (Y. pestis), a quadruple target real-time polymerase chain reaction assay was developed based on the specific target genes of Y.
Wenfang Wang, Xiaoxue Zhang, Hui Yu, Zhanli Wang   +3 more
doaj   +2 more sources

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, 2019
In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen, Gopal P Jadhav, Peter M Fischer   +2 more
exaly   +2 more sources

Single-Cell Sequencing Data Revealed Mechanisms of Interactions Between Tumor Cells and Cancer-Associated Fibroblasts in Metastatic Colorectal Cancer. [PDF]

Biomed Res Int
Colorectal cancer (CRC) is highly metastatic, yet the interaction between tumor cells and microenvironment components remains unclear, as does its impact on patient outcomes. Single‐cell data (GSE225857 and GSE166555) were collected for transformed and primary CRC to identify differing cell types and their subpopulations. Prognostic signature genes for
Tan Y, Yang Y, Tian F, Li N, Hu L, Deng M, Wang Y, Xia Z, Sun R.   +8 more
europepmc   +2 more sources

Dietary cauliflower (Brassica oleracea var. botrytis) mitigates benzo[a]pyrene-induced oxidative stress, immune dysfunction, and tissue damage in Nile tilapia [PDF]

Scientific Reports
Benzo[a]pyrene (BaP) is a ubiquitous polycyclic aromatic hydrocarbon that has been reported to induce immunotoxicity and oxidative stress in fish. In the current study, the potential protective efficacy of dietary cauliflower powder (CAF; Brassica ...
Zeinab El-Bouhy, Afaf N. Abdel Rahman, Fatma A. S. Mohamed, Mohamed W. A. Elashhab, Tarek Khamis, Rasha M. Reda   +5 more
doaj   +2 more sources

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications. [PDF]

Wiley Interdiscip Rev RNA
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Felicitus S, Pinto SS, Madagundapalli Ramakrishna SS, Nanjappa DP, Chakraborty G, Chakraborty A.   +5 more
europepmc   +2 more sources

Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features. [PDF]

Int J Cancer
What's New? Patient‐derived organoids provide a promising platform for modeling colorectal cancer. The authors demonstrated that organoids derived from normal colorectal tissue recapitulate the cellular composition and differentiation trajectory of colorectal crypts.
Yu Z, Derksen M, Te Pas BM, Ladstätter S, Overmeer R, Brazda P, van de Wetering M, Pourfarzad F, Vries RGJ, Megchelenbrink W, Bock C, Altucci L, Stunnenberg HG.   +12 more
europepmc   +2 more sources

Caffeine improves the shooting performance and reaction time of first-person shooter esports players: a dose-response study [PDF]

Frontiers in Sports and Active Living
Caffeine is recognized as one of the most effective dietary ergogenic aids in sports, yet its evidence-based effectiveness in esports is unclear. This study investigated the effects of two different doses of caffeine on the shooting performance and ...
Ethan J. Rogers, Michael G. Trotter, Daniel Johnson, Ben Desbrow, Ben Desbrow, Neil King   +5 more
doaj   +2 more sources

Yersinia pestis Caf1 Protein: Effect of Sequence Polymorphism on Intrinsic Disorder Propensity, Serological Cross-Reactivity and Cross-Protectivity of Isoforms. [PDF]

PLoS ONE, 2016
Yersinia pestis Caf1 is a multifunctional protein responsible for antiphagocytic activity and is a key protective antigen. It is generally conserved between globally distributed Y. pestis strains, but Y. pestis subsp.
Pavel Kh Kopylov, Mikhail E Platonov, Vitaly G Ablamunits, Tat'yana I Kombarova, Sergey A Ivanov, Lidiya A Kadnikova, Aleksey N Somov, Svetlana V Dentovskaya, Vladimir N Uversky, Andrey P Anisimov   +9 more
doaj   +1 more source