Subunits of the Histone Chaperone CAF1 Also Mediate Assembly of Protamine-Based Chromatin [PDF]
Cell Reports, 2013 One of the most dramatic forms of chromatin reorganization occurs during spermatogenesis, when the paternal genome is repackaged from a nucleosomal to a protamine-based structure. We assessed the role of the canonical histone chaperone CAF1 in Drosophila
Cécile M. Doyen +7 more
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The CAF1-NOT complex of trypanosomes [PDF]
Frontiers in Genetics, 2014 In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben +2 more
doaj +9 more sources
Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3 [PDF]
Epigenetics & Chromatin, 2023 Histone modifications are one of the many key mechanisms that regulate gene expression. Ash1 is a histone H3K36 methyltransferase and is involved in gene activation. Ash1 forms a large complex with Mrg15 and Caf1/p55/Nurf55/RbAp48 (AMC complex). The Ash1
Eojin Yoon, Ji-Joon Song
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CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury [PDF]
Journal of Inflammation Research, 2016 Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Shi JX, Li JS, Hu R, Li XM, Wang H
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Caf1A usher possesses a Caf1 subunit-like domain that is crucial for Caf1 fibre secretion [PDF]
Biochemical Journal, 2009 The chaperone/usher pathway controls assembly of fibres of adhesive organelles of Gram-negative bacteria. The final steps of fibre assembly and fibre translocation to the cell surface are co-ordinated by the outer membrane proteins, ushers. Ushers consist of several soluble periplasmic domains and a single transmembrane β-barrel.
Xiaodi, Yu +6 more
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Thermal stability and rheological properties of the ‘non-stick’ Caf1 biomaterial [PDF]
Biomedical Materials, 2017 The ability to culture cells in three-dimensions has many applications, from drug discovery to wound healing. 3D cell culture methods often require appropriate scaffolds that mimic the cellular environments of different tissue types. The choice of material from which these scaffolds are made is of paramount importance, as its properties will define the
Ulusu Y +6 more
openaire +6 more sources
The polymer and materials science of the bacterial fimbriae Caf1. [PDF]
Biomater Sci, 2023 Progress in revealing the rich polymer and materials science of Capsular antigen fragment 1 (Caf1), a bacterial fimbriae expressed by the bacterium Yersina pestis, is described.
Fulton DA, Dura G, Peters DT.
europepmc +5 more sources
Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forks. [PDF]
PLoS Genetics, 2011 Chromatin assembly mutants accumulate recombinogenic DNA damage and are sensitive to genotoxic agents. Here we have analyzed why impairment of the H3K56 acetylation-dependent CAF1 and Rtt106 chromatin assembly pathways, which have redundant roles in H3 ...
Marta Clemente-Ruiz +2 more
doaj +3 more sources
CAF1 plays an important role in mRNA deadenylation separate from its contact to CCR4 [PDF]
Nucleic Acids Research, 2007 The CAF1 protein is a component of the CCR4-NOT deadenylase complex. While yeast CAF1 displays deadenylase activity, this activity is not required for its deadenylation function in vivo, and CCR4 is the primary deadenylase in the complex. In order to identify CAF1-specific functional regions required for deadenylation in vivo, we targeted for ...
Ohn, Takbum +5 more
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Conformational states and association mechanism of Yersinia pestis Caf1 subunits [PDF]
Biochemical and Biophysical Research Communications, 2008 Bacterial infectivity often relies on efficient attachment to the host cells through adhesive extensions. Unveiling the structural basis of the formation of these organelles is of paramount importance for both academic and applicative implications.
Vitagliano Luigi +3 more
openaire +8 more sources