Results 91 to 100 of about 4,758 (202)

Anti‐proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase [PDF]

The EMBO Journal, 2011
Tob is a member of the anti-proliferative protein family, which functions in transcription and mRNA decay. We have previously demonstrated that Tob is involved in the general mechanism of mRNA decay by mediating mRNA deadenylation through interaction with Caf1 and a general RNA-binding protein, PABPC1.
Nao, Hosoda, Yuji, Funakoshi, Masato, Hirasawa, Ryota, Yamagishi, Yukako, Asano, Ryu, Miyagawa, Koichi, Ogami, Masafumi, Tsujimoto, Shin-ichi, Hoshino   +8 more
openaire   +2 more sources

Comprehensive Integrated Single‐Cell and Spatial Transcriptomics Unveil the Dynamic Landscape of Betel Nut‐Associated Oral Mucosal Carcinogenesis and Its Tumor Microenvironment

MedComm, Volume 7, Issue 6, June 2026.
ABSTRACT Betel nut chewing is a major etiological factor for oral squamous cell carcinoma (OSCC), yet its mechanistic underpinnings remain poorly defined. Here, we performed single‐cell RNA sequencing and spatial transcriptomics from six OSCC patients to comprehensively dissect the tumor microenvironment (TME) dynamics and cellular heterogeneity ...
Wei Dong, Shuojin Huang, Yijun Wu, Congyuan Cao, Jiaxue Li, Qianting He, Anxun Wang   +6 more
wiley   +1 more source

Protein engineering of Caf1 from the plague bacterium Yersinia pestis for tissue engineering applications

, 2016
30th Anniversary Symposium of the Protein-Society -- JUL 16-19, 2016 -- Baltimore, MDWOS:000387152400105Institute of Cellular and Molecular Bioscience, Medical School, University of Newcastle, UK, 2 Department of Bioengineering, Faculty of Engineering ...
Peters, Daniel, Ulusu, Yakup, Waller, Helen, Lakey, Jeremy   +3 more
core   +1 more source

Genetic dissection of plant architecture, development, and seed morphology in exotic × elite Upland cotton populations

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Cotton (Gossypium hirsutum L.) breeding has primarily emphasized fiber yield and quality, yet plant architectural, developmental, and seed morphological traits also play key roles in productivity and management. Here, we dissect the genetic basis of four such traits: plant height (HT), number of nodes with one branch (N1B), days to flowering ...
Hrithik Mangla, Ankush Sharma, Min Liu, Tariq Shehzad, Gary J. Pierce, Rahul Chandnani, Sayan Das, Sameer Khanal, Jason G. Wallace, John L. Snider, Don C. Jones, Peng W. Chee, Andrew H. Paterson   +12 more
wiley   +1 more source

Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo [PDF]

RNA, 2015
RNA-regulatory factors bound to 3′ UTRs control translation and stability. Repression often is associated with poly(A) removal. The deadenylase CAF1 is a core component of the CCR4–NOT complex. Our prior studies established that CAF1 represses translation independent of deadenylation.
Waghray, Shruti, Williams, Clay, Coon, Joshua J., Wickens, Marvin   +3 more
openaire   +2 more sources

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1672-1691, June 2026.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

Chaperone/usher machinery [PDF]

, 2012
Many virulence organelles of Gram-negative bacterial pathogens are assembled via the periplasmic chaperone/usher (CU) pathway. The assembly process is a complex task, involving secretion of organelle subunits via the two membranes and periplasm, subunit ...
Yu, Xiaodi
core   +1 more source

Transcriptome analysis reveals new microRNAs-mediated pathway involved in anther development in male sterile wheat

BMC Genomics, 2018
Background 337S is a novel bi-pole-photo-thermo-sensitive genic male sterile line in wheat, and sensitive to both long day length/high temperature and short day length/low temperature condition.
Longqing Sun, Genlou Sun, Chenxia Shi, Dongfa Sun   +3 more
doaj   +1 more source

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity

Nature Communications, 2022
Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers ...
Reuben Franklin, Yiming Guo, Shiyang He, Meijuan Chen, Fei Ji, Xinyue Zhou, David Frankhouser, Brian T. Do, Carmen Chiem, Mihyun Jang, M. Andres Blanco, Matthew G. Vander Heiden, Russell C. Rockne, Maria Ninova, David B. Sykes, Konrad Hochedlinger, Rui Lu, Ruslan I. Sadreyev, Jernej Murn, Andrew Volk, Sihem Cheloufi   +20 more
doaj   +1 more source

Challenges, Choices and Common Applications: Funders' Exercise of Power and Its Consequences for Nonprofits' Administrative Burden

Journal of Philanthropy, Volume 31, Issue 2, May 2026.
ABSTRACT The burdens faced by nonprofits applying for foundational support are increasingly acknowledged by practitioners, funders and other sectoral bodies. Attempts have been made to reduce these demands through common applications, structured sets of questions allowing simultaneous access to multiple funders.
Katy Adams
wiley   +1 more source