Results 91 to 100 of about 6,761 (193)
MedComm, Volume 6, Issue 11, November 2025.This review explores the multifaceted roles of cancer‐associated fibroblasts (CAFs) in tumor biology. It examines their diverse origins, dynamic activation via signaling pathways, and spatial–temporal heterogeneity, proposing an updated classification of eight distinct CAF subtypes. The review highlights CAFs' contributions to tumor growth, metastasis,
Chang Fan +4 more
wiley +1 more source
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
Nature Communications, 2022 Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers ...
Reuben Franklin +20 more
doaj +1 more source
Cell Proliferation, Volume 58, Issue 10, October 2025.RNF187 mediates the polyubiquitination and subsequent degradation of WDR77, reduces H4R3me2s catalysed by the WDR77/PRMT5 complex, and derepresses the transcription of EGR1, thereby promoting the proliferation and migration of human SSCs. ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING ...
Haoyue Hu +12 more
wiley +1 more source
BMC Genomics, 2018 Background 337S is a novel bi-pole-photo-thermo-sensitive genic male sterile line in wheat, and sensitive to both long day length/high temperature and short day length/low temperature condition.
Longqing Sun +3 more
doaj +1 more source
Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells [PDF]
, 2018 Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Afzal, Vackar +6 more
core +2 more sources
The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]
, 2012 XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Jones, Christopher Iain +2 more
core +1 more source
RNA‐binding proteins orchestrating immunity in plants
The Plant Journal, Volume 123, Issue 5, September 2025.SUMMARY RNA‐binding proteins (RBPs) direct the function and fate of RNA throughout the RNA lifecycle and play important roles in plant immunity, orchestrating the post‐transcriptional reprogramming of the transcriptome following induction of plant immune responses, a process that we term ‘RBP‐mediated immunity’. Although the importance of specific RBPs
Marcel Bach‐Pages +4 more
wiley +1 more source
Design of Multiplex Polymerase Chain Reaction (PCR) Method for Molecular Detection of Yersinia pestis Bacterium [PDF]
Cell Journal, 2010 Objective: Yersinia pestis, the causative agent of the zoonotic plague infection, is a majorpublic health concern both as a threat and potential bioweapon.
Mohammad Soleimani +7 more
doaj
PLoS Pathogens, 2019 With relatively few known specific transcription factors to control the abundance of specific mRNAs, Plasmodium parasites may rely more on the regulation of transcript stability and turnover to provide sufficient gene regulation.
Kevin J Hart +7 more
doaj +1 more source
Molecular Detection and Genotyping of Enterocytozoon bieneusi in Racehorses in China
Frontiers in Microbiology, 2019 Enterocytozoon bieneusi is a widely distributed human and animal pathogen. However, few data are available on the distribution of E. bieneusi genotypes in racehorses.
Aiyun Zhao +7 more
doaj +1 more source