Results 41 to 50 of about 3,383 (174)

Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites

Scientific Reports, 2017
Caffeic acid phenethyl ester (CAPE), extracted from propolis, was proven to inhibit colon cancer. Caffeic acid p-nitro-phenethyl ester (CAPE-pNO2), a derivative of CAPE, was determined to be an anti-platelet agent and a protector of myocardial ischaemia ...
Hao Tang, Xiaofang Yao, Cong Yao, Xiaoyan Zhao, Hua Zuo, Zhubo Li   +5 more
doaj   +1 more source

Glycosylation Enhances the Physicochemical Properties of Caffeic Acid Phenethyl Ester

Journal of Microbiology and Biotechnology, 2017
In this study, we synthesized a glycosylated derivative of caffeic acid phenethyl ester (CAPE) using the amylosucrase from Deinococcus geothermalis with sucrose as a substrate and examined its solubility, chemical stability, and anti-inflammatory activity.
Keum-Ok, Moon, Soyoon, Park, Myungsoo, Joo, Ki-Tae, Ha, Nam-In, Baek, Cheon-Seok, Park, Jaeho, Cha   +6 more
openaire   +2 more sources

Optimized enzymatic synthesis of caffeic acid phenethyl ester by RSM

New Biotechnology, 2010
In this study, optimization of enzymatic synthesis of caffeic acid phenethyl ester (CAPE), catalyzed by immobilized lipase (Novozym 435) from Candida antarctica was investigated. Novozym 435 was used to catalyze caffeic acid and 2-phenylethanol in an isooctane system.
Hsiao-Ching, Chen, Hen-Yi, Ju, Yawo-Kuo, Twu, Jiann-Hwa, Chen, Chieh-Ming J, Chang, Yung-Chuan, Liu, Cheng, Chang, Chwen-Jen, Shieh   +7 more
openaire   +2 more sources

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva, Yanqi Dai, Shervanthi Homer‐Vanniasinkam, Mohan Edirisinghe   +3 more
wiley   +1 more source

Bioactivity and Chemical Synthesis of Caffeic Acid Phenethyl Ester and Its Derivatives

Molecules, 2014
Caffeic acid phenethyl ester (CAPE), as one of the main active ingredients of the natural product propolis, shows the unique biological activities such as anti-tumor, anti-oxidation, anti-inflammatory, immune regulation, and so on. These have attracted
Pengxuan Zhang, Yuping Tang, Nian-Guang Li, Yue Zhu, Jin-Ao Duan   +4 more
doaj   +1 more source

Propolis‐Based Hybrid Nanoflowers as Multifunctional Nanozymes: Structural Integration of Polyphenols for Enhanced Catalytic and Antioxidant Activity

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT Propolis is a polyphenol‐rich natural resin with well‐documented antioxidant activity; however, its practical application is restricted by poor aqueous solubility and limited stability. Herein, propolis‐based organic–inorganic hybrid nanoflowers (Prp‐Nfs) were synthesized by integrating a propolis extract into a Cu3(PO4)2·3H2O matrix under ...
Cevahir Altinkaynak, Fatih Kirmizikar
wiley   +1 more source

Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity

Antioxidants, 2021
Caffeic acid phenethyl ester (CAPE) and its structurally-related caffeic acid (CA), ferulic acid (FA) and ethyl ferulate (EF) are constituents of honeybee propolis that have important pharmacological activities. This study found that CAPE—but not CA, FA,
Bo Shao, Li Mao, Miao Tang, Zhu-Ying Yan, Jie Shao, Chun-Hua Huang, Zhi-Guo Sheng, Ben-Zhan Zhu   +7 more
doaj   +1 more source

Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti‐Wrinkle Efficacy

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background We recently demonstrated in a randomized controlled trial (RCT) that a Standardized Propolis Extract (SPE), produced via a patented non‐alcoholic PEG 400/lecithin process, achieves significant clinical anti‐wrinkle efficacy (34% wrinkle depth reduction).
Božo Radić, Jelena Šuran
wiley   +1 more source

Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems [PDF]

Pharmacia, 2019
Propolis is a natural product with a plethora of biological effects, utilized by traditional medicine since antiquity. However, its application as a pharmaceutical is hindered by its variable composition and difficult standardization. CAPE has been shown
Yordan Yordanov
doaj   +3 more sources

Evaluation of ASC as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton, Joshua A. Kulas, Jiahui Liu, Nidhi Walia, Claudia Rangel‐Barajas, Travis Johnson, Jie Zhang, Kun Huang, Andrew D. Mesecar, Jeffrey L. Dage, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson   +12 more
wiley   +1 more source