Results 61 to 70 of about 8,207 (238)

Novel Oxadiazole‐Based Bioisostere of Caffeic Acid Phenethyl Ester: Synthesis, Anticancer Activity, and Inhibition of Lipoxygenase Product Biosynthesis

Drug Development Research, Volume 86, Issue 3, May 2025.
ABSTRACT Caffeic acid phenethyl ester (1), a honeybee propolis component, possesses many bioactive properties, making it a useful scaffold for drug research. Further, CAPE (1) is a more effective inhibitor of the biosynthesis of 5‐lipoxygenase (5‐LO) products compared to Zileuton, the only clinically‐approved direct 5‐LO inhibitor.
Mika A. Robichaud, Audrey Isabel Chiasson, Jérémie A. Doiron, Mathieu P. A. Hébert, Marc E. Surette, Mohamed Touaibia   +5 more
wiley   +1 more source

Harnessing Jasminum Bioactive Compounds: Updated Insights for Therapeutic and Food Preservation Innovations

Food Frontiers, Volume 6, Issue 3, Page 1093-1128, May 2025.
Jasminum bioactives improve food preservation by providing antimicrobial and antioxidant effects, especially when incorporated into active packaging, edible films, and nanoformulations that enhance stability and controlled release. They also offer many pharmacological benefits, including anti‐inflammatory, neuroprotective, and wound‐healing properties.
Antonio Rescigno, Paolo Zucca, Stefania Peddio, Sriranjani Srikanth, Niharika Prakash Kaushik, Nanjangud Venkatesh Anil Kumar, Gerardo Leyva‐Gómez, Dorota Kregiel, Ibrahim M. Abu‐Reidah, Surjit Sen, Krishnendu Acharya, William N. Setzer, Marta Palma‐Morales, Miquel Martorell, Daniela Calina, Celia Rodríguez‐Pérez, Javad Sharifi‐Rad, William C. Cho   +17 more
wiley   +1 more source

Caffeic acid phenethyl ester inhibits liver fibrosis in rats

World Journal of Gastroenterology, 2015
To investigate the hepatoprotective effects and antioxidant activity of caffeic acid phenethyl ester (CAPE) in rats with liver fibrosis.A total of 75 male Sprague-Dawley rats were randomly assigned to seven experimental groups: a normal group (n = 10), a vehicle group (n = 10), a model group (n = 15), a vitamin E group (n = 10), and three CAPE groups ...
Ning Yang, Mei Li, Yaping Li, Juan-Juan Shi, Shuangsuo Dang, Xiu-Fang Wang, Song Zhai   +6 more
openaire   +3 more sources

One-pot esterification and amidation of phenolic acids [PDF]

, 2014
We developed a new one-pot reaction of phenolic acids to afford the corresponding esters and amides through acyl-protected and activated phenolic acid intermediates.
Aoyama, Toshifumi, Koyama, Masahiro, Nakajima, Takero, Nakamura, Kozo, Okitsu, Sho   +4 more
core   +1 more source

ミツバチのプロポリスの生理活性: 抗ストレス活性および抗癌活性に対する分子生物学的解析 [PDF]

, 2022
筑波大学University of Tsukuba博士（病態機構学）Doctor of Philosophy in Disease Mechanism2022この博士論文は、全文公表に適さないやむを得ない事由があり要約のみを公表していましたが、解消したため、令和6(2024)年10月10日に全文を公表しました。doctoral ...
Ashish, KAUL
core   +1 more source

Propolis Extract Reduces Doxorubucin‐Induced Brain Damage by Regulating Inflammation, ER Stress, Oxidative Stress, and Apoptosis

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
PROP demonstrated protective effects against DOX‐induced oxidative stress, inflammation, and apoptosis in brain tissue by reducing MDA levels while increasing GSH, SOD, and CAT activities. It also attenuated DOX‐induced increases in inflammatory and apoptotic markers such as TNF‐α, IL‐1β, IL‐6, NF‐kB, iNOS, and CASP‐3 while restoring PI3K, mTOR, AKT ...
Volkan Gelen, Mehmet Başeğmez, İnan Dursun, Irfan Çinar, Adem Kara   +4 more
wiley   +1 more source

Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

Frontiers in Physiology, 2020
Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic acids with an interesting array of biological activities; e.g., antioxidant, anti-inflammatory, antimicrobial and cytostatic.
Henrique Silva, Henrique Silva, Nuno Miguel F. Lopes   +2 more
doaj   +1 more source

分子経路の理解と治療を目指したハイポキシアの制御に関する研究 [PDF]

, 2018
筑波大学 (University of Tsukuba ...
Bhargava Priyanshu
core   +1 more source

The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications

Advanced Science, Volume 12, Issue 10, March 13, 2025.
BACH1, a basic leucine zipper protein ubiquitously expressed in mammalian tissues, plays a critical role in the regulation of oxidative stress, cell cycle progression, heme homeostasis, and immune responses. It is implicated in cardiovascular diseases, cancer progression, neurodegenerative disorders, and many other diseases.
Xiangxiang Wei, Yunquan He, Yueyang Yu, Sichong Tang, Ruiwen Liu, Jieyu Guo, Qingjun Jiang, Xiuling Zhi, Xinhong Wang, Dan Meng   +9 more
wiley   +1 more source

Water-Mediated Synthesis of (E)-3-(1-Methyl-1H-benzo[d]imidazol-5-yl)-N-phenethylacrylamide, a Caffeic Acid Phenethyl Amide Analogue

Molbank
Caffeic acid phenethyl ester (CAPE) is a phenolic natural product with diverse biological activities, notably anticancer properties. However, its ester group is metabolically unstable.
Muppidi Subbarao, Sean M. Kerwin
doaj   +1 more source