Results 71 to 80 of about 3,383 (174)

“Molecular Docking and Dynamic Studies of Amide Derivatives from Cinnamic Acid with Potential Anti‐Dengue Virus Activity”

ChemistryOpen, Volume 14, Issue 11, November 2025.
A library of easily synthesizable CAPE analogs was screened in silico against the dengue virus envelope protein. Compound LQM778 showed stable binding and promising inhibitory potential. This study highlights LQM778 as a candidate for future in vitro validation and structural optimization toward accessible antiviral agents against dengue.
Luis Alfonso Cárdenas‐Granados, Manuel Alejandro Hernández‐Serda, Omar Joel Villegas‐Solís, Víctor Hugo Vázquez‐Valadez, Aldo Yoshio Alarcón‐López, Pablo A. Martínez‐Soriano, Jaqueline Ramos‐Sánchez, Tannya Karen Castro‐Jiménez, José Bustos‐Arriaga, Enrique Angeles   +9 more
wiley   +1 more source

Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives

Biomolecules, 2020
Caffeic acid (CA) and its derivatives caffeic acid phenethyl ester (CAPE) and chlorogenic acid (CGA) are phenolic compounds of plant origin with a wide range of biological activities. Here, we identify and characterize their inhibitory properties against
Liza Ulčakar, Marko Novinec
doaj   +1 more source

RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Maternal obesity (MO) accounts for more than 40% of pregnancies in the United States, induces inflammation, and impairs embryonic myogenesis, known to program muscle dysfunction in offspring. Inflammation enhances the binding of RelA to a novel distal enhancer located 4 kb upstream of myogenin promoter to inhibit embryonic myogenesis, which is ...
Md Nazmul Hossain, Yao Gao, Sharmeen Islam, Li‐Wei Chen, Xinrui Li, Zhongyun Kou, Nathan C Law, Jeanene Marie de Avila, Mei‐Jun Zhu, Min Du   +9 more
wiley   +1 more source

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and Tyk2 Inhibitors via Interleukin‐10 Antagonism

Arthritis &Rheumatology, Volume 77, Issue 10, Page 1373-1386, October 2025.
Objective JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but Tyk2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn disease, which highlights the complex role for JAK/STAT signaling in different inflammatory processes.
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbury, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

Caffeic Acid Phenethyl Ester and Ethanol Extract of Propolis Induce the Complementary Cytotoxic Effect on Triple-Negative Breast Cancer Cell Lines

Molecules, 2015
Chemotherapy of breast cancer could be improved by bioactive natural substances, which may potentially sensitize the carcinoma cells’ susceptibility to drugs. Numerous phytochemicals, including propolis, have been reported to interfere with the viability
Anna Rzepecka-Stojko, Agata Kabała-Dzik, Aleksandra Moździerz, Robert Kubina, Robert D. Wojtyczka, Rafał Stojko, Arkadiusz Dziedzic, Żaneta Jastrzębska-Stojko, Magdalena Jurzak, Ewa Buszman, Jerzy Stojko   +10 more
doaj   +1 more source

Preliminary Characterization of Monofloral Helianthus annuus L. Bee Pollen Using Advanced Analytical Techniques: A Comparative Study With Polyfloral Pollen

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This study characterized monofloral sunflower bee pollen using palynological, physicochemical, and metabolomic analyses. LC–MS/MS results revealed significantly higher hyperoside levels in the monofloral pollen. The data obtained support the potential of sunflower pollen in functional food formulations.
Nazlıcan Yıldırım, Yusuf Can Gerçek
wiley   +1 more source

New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition

Journal of Chemistry, 2017
Leukotrienes are biosynthesized by the conversion of arachidonic acid by 5-Lipoxygenase and play a key role in many inflammatory disorders. Inspired by caffeic acid phenylethyl ester (CAPE) (2) and an analog carrying a triazole substituted by cinnamoyl ...
Pierre-Philipe Roy, Diene Faye, Sébastien Blanchard, Marc Cormier, Jérémie A. Doiron, Marc E. Surette, Mohamed Touaibia   +6 more
doaj   +1 more source

Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro

Redox Biology, 2018
Caffeic acid phenethyl ester (CAPE) could ameliorate myocardial ischemia/reperfusion injury (MIRI) by various mechanisms, but there hadn’t been any reports on that CAPE could regulate silent information regulator 1 (SIRT1) and endothelial nitric oxide ...
Dejuan Li, Xiaoling Wang, Qin Huang, Sai Li, You Zhou, Zhubo Li   +5 more
doaj   +1 more source

Protective role of caffeic acid phenethyl ester against tetramethrine-induced toxicity in mice

Medicine Science, 2016
The purpose of this study was to determine the biochemical, histopathological and genotoxic effects of tetramethrine, which is widely used in domestic and agricultural activities as well as identify the protective effect of caffeic acid phenethyl ester (
Gokhan Nur, Haci Ahmet Deveci, Yusuf Ersan, Oguz Merhan, Mumtaz Nazli, Ozlem Nur   +5 more
doaj   +1 more source

The neuroprotective effects of caffeic acid phenethyl ester against methamphetamine-induced neurotoxicity

Ecotoxicology and Environmental Safety
Methamphetamine (METH) is a highly abused substance on a global scale and has the capacity to elicit toxicity within the central nervous system. The neurotoxicity induced by METH encompasses neuronal degeneration and cellular demise within the substantia
Bin Yang, Xiaohui Tan, Yuzhen Chen, Jing Lin, Jingjie Liang, Xia Yue, Dongfang Qiao, Huijun Wang, Sihao Du   +8 more
doaj   +1 more source