Results 101 to 110 of about 662,429 (302)

A contemporary simple risk score for prediction of severe acute kidney injury after heart transplantation

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1166-1175, April 2025.
A contemporary simple risk score for prediction of severe AKI after HT. Abstract Background The aim of this study was to develop a simple risk score to estimate severe acute kidney injury (AKI) risk based on a large contemporary heart transplantation (HT) cohort.
Shuangshuang Zhu   +10 more
wiley   +1 more source

Calcineurin-NFAT signaling pathway.

open access: yes
Calcium-mediated signaling is involved in the activation of diverse subsets of gene transcription, including GZMB. Target gene expression can change with the activation of transcriptional factors in response to electrical stimulation, thus providing a ...
Minseon Lee (18404208)   +1 more
core   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira   +12 more
wiley   +1 more source

ATOPIC DERMATITIS: NEW ASPECTS OF TREATMENT

open access: yesВопросы современной педиатрии, 2013
Atopic dermatitis is a chronic inflammatory cutaneous disease, which demands a prolonged treatment. A modern views on the main approaches to treatment of atopic dermatitis in children and adults are analyzed in this article. The treatment is based on the
D. Sh. Macharadze
doaj   +1 more source

Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A

open access: yes, 2012
<b>Introduction:</b> Cardiac remodelling is controlled by complex systems, including activation of the renin-angiotensin system (RAS) and signalling through MAP kinases and Ca2+-activated calcineurin.
Touyz, R.M., Montezano, A.C., White, M.
core   +1 more source

Untethered Electrical Stimulation Using Optoelectricity and Piezoelectricity for Tissue Regeneration

open access: yesFlexTech, EarlyView.
Untethered electrical stimulation from optoelectronic and piezoelectric materials can aid regeneration of damaged tissue. ABSTRACT Electrical signals are increasingly recognized as important regulators of tissue development and regeneration, with outcomes linked to behaviors including proliferation, differentiation, cell migration, and more.
Ryan Yao, Baochun Xu, Cunjiang Yu
wiley   +1 more source

Fungal Morphology in Resistance to Calcineurin Inhibitors and Host - Pathogen Interactions

open access: yes, 2020
This item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.Fungal dimorphism is the ability of a fungus to switch ...
Vellanki, Sandeep
core   +1 more source

Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy

open access: yesEMBO Molecular Medicine, 2017
Myeloid leucocytes mediate host protection against infection and critically regulate inflammatory responses in body tissues. Pattern recognition receptor signalling is crucial for myeloid cell responses to pathogens, but growing evidence suggests an ...
Kamila Bendickova   +2 more
doaj   +1 more source

Progress in the Role of Mast Cells and Biomolecular Signals in the Mechanism of Postoperative Ileus: From Cellular Activation to Exploration of the Brain–Gut Axis

open access: yesGut Medicine, EarlyView.
ABSTRACT Postoperative ileus (POI) is a frequent complication after surgical procedures, predominantly manifesting as aberrant gastrointestinal motility, which markedly extends the duration of postoperative recovery for patients. The clinical duration of POI is typically modulated by intricate inflammatory cascades, with mast cells assuming a critical ...
Tian‐le Zhang   +4 more
wiley   +1 more source

In silico binding affinity study of calcineurin inhibitors to calcineurin and its close associates

open access: yes, 2013
Calcineurin (CN) is a calcium regulated serine/threonine protein phosphatase. It is known to be inhibited by cyclosporin A (CsA), tacrolimus (FK506), endothall (ENDO), microcystin (MCYST), okadaic acid (OA) and trifluoperazine (TFP).
Devaraju, K.S.   +6 more
core  

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