Results 81 to 90 of about 662,429 (302)

Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates [PDF]

Current Medical Mycology
Background and Purpose: The high morbidity and mortality caused by invasive mold infections require new and effective treatment strategies. Heat shock proteins, which are found in all living organisms, play a role in the homeostatic control of the cell ...
Nuri Kiraz, Sümeyye Şen Kaya, Ayşe Barış, Deniz Turan, Yasemin Öz, İlknur Dağ   +5 more
doaj   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source

ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION

Вестник трансплантологии и искусственных органов, 2016
In recent years the success of transplantation is associated primarily with extensive use of calcineurin inhibitors (CNIs) – cyclosporine and tacrolimus which became the basis of the various immunosuppressive therapy protocols.
D. V. Doronin, A. M. Chernyavskiy, A. V. Fomichev, M. N. Deryagin, V. N. Gorbatykh   +4 more
doaj   +1 more source

Treatment with Glucocorticoids or Calcineurin Inhibitors in Primary FSGS [PDF]

, 2016
In primary FSGS, calcineurin inhibitors have primarily been studied in patients deemed resistant to glucocorticoid therapy. Few data are available about their use early in the treatment of FSGS.
Bethany J. Foster, Laurin, Louis-Philippe, Caroline J. Poulton, Patrick H. Nachman, Falk, Ronald J., Poulton, Caroline J., Susan L. Hogan, Gasim, Adil M., J. Charles Jennette, Adil M. Gasim, Charles Jennette,, Ronald J. Falk, Foster, Bethany J., Louis-Philippe Laurin, Hogan, Susan L., Nachman, Patrick H.   +15 more
core   +1 more source

Interferon-gamma rescues dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching

iScience
Summary: Invasive pulmonary aspergillosis is a lethal opportunistic fungal infection in transplant recipients receiving calcineurin inhibitors. We previously identified a role for the calcineurin pathway in innate immune responses to A.
Amit Adlakha, Thomas J. Williams, Xinxin Shou, Anna K. Reed, Boris Lenhard, Darius Armstrong-James   +5 more
doaj   +1 more source

Calcineurin Inhibitors in Membranous Nephropathy [PDF]

Kidney International Reports, 2021
Ponticelli, Claudio, Praga, Manuel, Moroni, Gabriella   +2 more
openaire   +3 more sources

Outcomes in Progressive Pulmonary Fibrosis in Systemic Autoimmune Rheumatic Diseases: Real‐World Data From the ILD‐PRO Registry

Arthritis &Rheumatology, EarlyView.
Objective We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease–associated progressive pulmonary fibrosis (SARD‐PPF) and evaluated whether outcomes differed by SARD subtype. Methods The ILD‐PRO Registry is a prospective multicenter US registry of patients with PPF.
Sonali J. Bracken, Jeremy M. Weber, Megan L. Neely, Aparna C. Swaminathan, Scott M. Palmer, Erin M. Wilfong, Ann D. Chauffe, Elizabeth R. Volkmann   +7 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Monocellular and Multicellular Parasites Infesting Humans: A Review of Calcium Ion Mechanisms

Biomedicines
Calcium (Ca2+) is a signal messenger for ion flow in and out of microbial, parasitic, and host defense cells. Manipulation of calcium ion signaling with ion blockers and calcineurin inhibitors may improve host defense while decreasing microbial/parasitic
John A. D’Elia, Larry A. Weinrauch
doaj   +1 more source

Pathogenesis of calcineurin inhibitor-induced hypertension

, 2012
This article reviews the current understanding of the mechanisms of calcineurin inhibitor-induced hypertension. Already early after the introduction of cyclosporine in the 1980s, vasoconstriction, sympathetic excitation and sodium retention by the kidney
Hoorn, Ewout, Unwin, RJ, McCormick, JA, Walsh, S.B. (Stephen), Hoorn, Ewout; id_orcid, Zietse, R., Ellison, D.H. (David), Hoorn, E.J. (Ewout), Zietse, R. (Bob), Ellison, DH, McCormick, J.A. (James), Unwin, R.J. (Robert John), Walsh, SB   +12 more
core   +1 more source