Results 161 to 170 of about 662,429 (302)

Optimizing cord blood unit selection to improve survival after single‐unit unrelated cord blood transplantation for adult myelodysplastic syndrome

British Journal of Haematology, EarlyView.
Summary Unrelated cord blood transplantation (CBT) is an important alternative donor option for adult patients with myelodysplastic syndrome (MDS); however, the prognostic significance of cord blood unit characteristics following CBT remains unclear and may vary according to disease risk.
Takaaki Konuma, Machiko Fujioka, Kyoko Fuse, Tatsuya Suwabe, Hiroki Hosoi, Naoyuki Uchida, Masatsugu Tanaka, Kazuto Ogura, Satoshi Takahashi, Makoto Onizuka, Takeshi Maeda, Noriko Doki, Yasufumi Uehara, Atsushi Wake, Masatoshi Sakurai, Naoyuki Anzai, Toshimitsu Ueki, Yoshiko Matsuhashi, Koji Kawamura, Fumihiko Ishimaru, Junya Kanda, Marie Ohbiki, Yoshiko Atsuta, Hidehiro Itonaga   +23 more
wiley   +1 more source

Electrolyte disturbances after allogeneic hematopoietic cell transplantation in patients receiving calcineurin inhibitors: incidence and severity. [PDF]

Front Pharmacol
Ferreira Camargo MC, da Costa-Junior LC, Izu M, de Cássia Barbosa da Silva Tavares R, Maradei Pereira SC, Atta EH, Rodrigues Moreira MC, Nogueira MC, Lerner D, de Souza Fernandez T, Júnior Lima Santos PC.   +10 more
europepmc   +1 more source

Is It Time to Repurpose Calcineurin Inhibitors for the Treatment of Cognitive Impairment and Dementia? [PDF]

J Alzheimers Dis, 2023
Norris CM.
europepmc   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease. [PDF]

Crohns Colitis 360, 2022
Kawaguchi T, Fukata M, Omori T, Kiyohara H, Sugimoto S, Nanki K, Sujino T, Mikami Y, Kanai T.   +8 more
europepmc   +1 more source

Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells

, 2012
[[abstract]]Evidences suggest that lipopolysaccharide (LPS) participates in the inflammatory response in the cardiovascular system; however, it is unknown if LPS is sufficient to cause the cardiac hypertrophy.
Liu, Chung-Jung;Cheng, Yi-Chang;Lee, Kung-Wei;Hsu, Hsi-Hsien;Chu, Chun-Hsien;Tsai, Fuu-Jen ;Tsai, Chang-Hai;Chu, Chia-Yih;Liu, Jer-Yuh;Kuo, Wei-Wen;黃志揚;HUANG, CHIH-YANG
core  

Elevated IL‐4 and IL‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond, Victoria Soto, Beatriz Abdo Abujamra, Franco Rongioletti, John A. McGrath, Ivan Jozic, Paolo Romanelli   +6 more
wiley   +1 more source

Kidney adverse events associated with calcineurin inhibitors: a real-world study based on the FAERS database and network pharmacology. [PDF]

Front Med (Lausanne)
Liang Y, Tan X, Dai Q, Liu J.
europepmc   +1 more source

Cold plasma treatment for oral lichen planus: a retrospective case collection and proposal of a new clinical score

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Oral lichen planus (OLP) is a chronic autoimmune mucosal disease with malignant potential and limited treatment options. This study evaluated the long‐term efficacy and safety of cold atmospheric plasma (CAP) therapy in therapy‐refractory OLP and introduced the novel Lichen Planus Severity Score (LPSS).
Christian Seebauer, Hans‐Robert Metelmann, Mohamed Falougy, Wolfram Kaduk, Lasse Kremer, Georg Daeschlein   +5 more
wiley   +1 more source