Results 221 to 230 of about 74,317 (300)

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1181-1194, November 2026.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

[Effect of inferior alveolar nerve transection on mandibular condyles in rats and the repair effect of calcitonin gene-related peptide]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Zhang M, Cheng K, Li J, Liu Z, Jiang T.
europepmc   +1 more source

Old disease, new twist

Journal of Hospital Medicine, Volume 21, Issue 11, Page 1305-1309, November 2026.
Abstract An 81‐year‐old man with a history of high‐grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9‐day course of
Hadi Roudsari, Gurpreet Dhaliwal, Anand D. Jagannath, Alan H. Baik, Sam Brondfield   +4 more
wiley   +1 more source

Prognostic Factors in Medullary Thyroid Cancer: A Real-World Study in a Referral Center. [PDF]

Biomedicines
Lauretta R, Puliani G, Terrenato I, Bianchini M, Mormando M, Appetecchia M.   +5 more
europepmc   +1 more source

Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough

The Laryngoscope, Volume 136, Issue 11, Page 4938-4944, November 2026.
The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen, Carmen Esna, Camille Prigent, Anna Miles   +3 more
wiley   +1 more source

Surgical extent, tumor size, and calcitonin levels in medullary thyroid carcinoma: impact on oncologic outcomes in a retrospective cohort study. [PDF]

BMC Cancer
Köroğlu EY, Evranos Öğmen B, Deniz MS, Saylam B, Ahsen H, Aydin C, Topaloğlu O, Ersoy R, Çakir B.   +8 more
europepmc   +1 more source

Postoperative Hypocalcemia Following Total Thyroidectomy Versus Completion Thyroidectomy

The Laryngoscope, Volume 136, Issue 11, Page 5094-5100, November 2026.
Completion thyroidectomy performed with at least a three‐month interval demonstrates superior parathyroid preservation compared to primary total thyroidectomy, as evidenced by significantly higher postoperative parathyroid hormone levels (51.90 ± 30.26 pg/mL vs. 30.90 ± 17.10 pg/mL, p = 0.006).
Mehmet Turan Cicek, Çiğdem Firat Koca, Mehmet Tan, Baransel Algan   +3 more
wiley   +1 more source

Tendinopathy: Types, Epidemiology, Molecular Mechanisms, and Future Precision‐Oriented Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
This review presents tendinopathy as a heterogeneous disorder driven by dynamic interactions among mechanical sensing, inflammation, angiogenesis and innervation, and extracellular matrix remodeling. Integrating clinical phenotypes with imaging, biomarkers, and multi‐omics may enable molecular subtyping and mechanism‐guided interventions, advancing ...
Yang Wu, Junyi Long, Meng Yang, Hongjie Huang, Jianquan Wang   +4 more
wiley   +1 more source

“What Medical Management Should Be First Line for Bladder Storage Symptoms in NLUTD”—Pro Botox

Neurourology and Urodynamics, Volume 45, Issue 8, Page 1479-1481, November 2026.
ABSTRACT Objectives Neurogenic lower urinary tract dysfunction (NLUTD) severely impairs patient quality of life (QoL). While oral medications are often first‐line treatments, their high failure rates and side effects limit their effectiveness. Thus, we argue for the use of intravesical botulinum toxin A (BoNT‐A) injections as a first‐line alternative ...
Vada Furlan, Alyssa Kobayashi, Zhina Sadeghi   +2 more
wiley   +1 more source