Results 1 to 10 of about 42,581 (243)

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study [PDF]

Biomedicines, 2021
Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 ...
Joaquim Oristrell, Joan Carles Oliva, Isaac Subirana, Enrique Casado, Didier Domínguez, Andrea Toloba, Patricia Aguilera, Joan Esplugues, Pilar Fafián, Maria Grau   +9 more
doaj   +2 more sources

Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy. [PDF]

PLoS ONE, 2012
Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle progression and tumorigenesis.
Janice García-Quiroz, Rocío García-Becerra, David Barrera, Nancy Santos, Euclides Avila, David Ordaz-Rosado, Mariana Rivas-Suárez, Ali Halhali, Pamela Rodríguez, Armando Gamboa-Domínguez, Heriberto Medina-Franco, Javier Camacho, Fernando Larrea, Lorenza Díaz   +13 more
doaj   +3 more sources

Early growth inhibition is followed by increased metastatic disease with vitamin D (calcitriol) treatment in the TRAMP model of prostate cancer.

PLoS ONE, 2014
The active metabolite of vitamin D3, 1,25-dihydroxyvitamin D3 (calcitriol) has antiproliferative effects in non-aggressive prostate cancer, however, its effects in more aggressive model systems are still unclear.
Adebusola Alagbala Ajibade, Jason S Kirk, Ellen Karasik, Bryan Gillard, Michael T Moser, Candace S Johnson, Donald L Trump, Barbara A Foster   +7 more
doaj   +2 more sources

Modulation of renal inflammation and tubular injury by calcitriol in patients with early diabetic kidney disease: a randomized controlled trial [PDF]

Annals of Medicine
Introduction Diabetic kidney disease (DKD) is marked by inflammation, fibrosis and oxidative stress. Calcitriol may offer renoprotective effects by modulating these processes.
Pringgodigdo Nugroho, Aida Lydia, Pradana Soewondo, Suhardjono, Ina Susianti Timan, Kuntjoro Harimurti, Zulkhair Ali   +6 more
doaj   +2 more sources

Head-to-head comparison of tazarotene and calcitriol with or without sequential therapy in mild-to-moderate psoriasis: A randomized open-label study

Journal of Research in Pharmacy Practice, 2023
Objective: Psoriasis is an autoimmune disease that causes rapid turnover of skin cells. It is a chronic disease that affects a patient's quality of life significantly and frequently requires long-term treatment.
Jaspreet Kaur Sidhu, Prithpal Singh Matreja, Ashwani Kumar Gupta, Amandeep Singh, Surjit Singh   +4 more
doaj   +1 more source

Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells

Biotechnology & Biotechnological Equipment, 2021
Glioma is the most prevalent and lethal type of primary tumor of central nervous system. The regulatory role of calcitriol, the active form of vitamin D3, has been determined in various cellular processes including cell survival and apoptosis.
Ozlem Kucukhuseyin, Aris Cakiris, Mehmet Tolgahan Hakan, Cem Horozoglu, Erdem Tuzun, Ilhan Yaylim   +5 more
doaj   +1 more source

Mitochondrial potassium channels: A novel calcitriol target

Cellular & Molecular Biology Letters, 2022
Background Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR).
Anna M. Olszewska, Adam K. Sieradzan, Piotr Bednarczyk, Adam Szewczyk, Michał A. Żmijewski   +4 more
doaj   +1 more source

Peptide receptor radionuclide therapy controls inappropriate calcitriol secretion in a pancreatic neuro-endocrine tumor: a case report

BMC Gastroenterology, 2020
Background Hypercalcemia of malignancy is not uncommon in patients with advanced stage cancer. In rare cases the cause of the hypercalcemia is excessive production of calcitriol, the active form of vitamin D.
Maarten Haemels, Thierry Delaunoit, Koen Van Laere, Eric Van Cutsem, Chris Verslype, Christophe M. Deroose   +5 more
doaj   +1 more source

The ERRα–VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR‐CYP24A1‐ERRα overexpression correlates with poor prognosis in patients with basal‐like breast cancer

Molecular Oncology, 2022
Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol,
Katia Danza, Letizia Porcelli, Simona De Summa, Roberta Di Fonte, Brunella Pilato, Rosanna Lacalamita, Simona Serratì, Amalia Azzariti, Stefania Tommasi   +8 more
doaj   +1 more source

Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction

Cells, 2022
Background: Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied the therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms.
Simin Yang, Chunmiao Wang, Chengshao Ruan, Meiling Chen, Ran Cao, Liang Sheng, Naiying Chang, Tong Xu, Peiwen Zhao, Xuesheng Liu, Fengqin Zhu, Qingzhong Xiao, Shan Gao   +12 more
doaj   +1 more source