Results 1 to 10 of about 49,400 (296)

Mitochondrial potassium channels: A novel calcitriol target

Cellular & Molecular Biology Letters, 2022
Background Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR).
Anna M. Olszewska, Adam K. Sieradzan, Piotr Bednarczyk, Adam Szewczyk, Michał A. Żmijewski   +4 more
doaj   +2 more sources

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study

Biomedicines, 2021
Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 ...
Joaquim Oristrell, Joan Carles Oliva, Isaac Subirana, Enrique Casado, Didier Domínguez, Andrea Toloba, Patricia Aguilera, Joan Esplugues, Pilar Fafián, Maria Grau   +9 more
doaj   +2 more sources

Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism

Molecular Medicine, 2021
Background The present study aimed to further explore the potential interaction between oxidative stress and autophagy in the progression of traumatic brain injury (TBI) and therapeutic mechanism of calcitriol, the active form of vitamin D (VitD ...
Changmeng Cui, Changshui Wang, Feng Jin, Mengqi Yang, Lingsheng Kong, Wenxiu Han, Pei Jiang   +6 more
doaj   +2 more sources

Bioconversion of vitamin D3 to bioactive calcifediol and calcitriol as high-value compounds

Biotechnology for Biofuels and Bioproducts, 2022
Biological catalysis is an important approach for the production of high-value-added compounds, especially for products with complex structures. Limited by the complex steps of chemical synthesis and low yields, the bioconversion of vitamin D3 (VD3) to ...
Zheyi Wang, Yan Zeng, Hongmin Jia, Niping Yang, Mengshuang Liu, Mingyue Jiang, Yanning Zheng   +6 more
doaj   +2 more sources

Calcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells

Frontiers in Endocrinology, 2020
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options.
Iacopo Gesmundo, Francesca Silvagno, Dana Banfi, Valentina Monica, Valentina Monica, Alessandro Fanciulli, Giacomo Gamba, Noemi Congiusta, Roberta Libener, Chiara Riganti, Ezio Ghigo, Riccarda Granata   +11 more
doaj   +2 more sources

Calcitriol Suppresses Warburg Effect and Cell Growth in Human Colorectal Cancer Cells

Life, 2021
Increasing lines of evidence indicate that the biologically active form of vitamin D, calcitriol (1,25-dihydroxyvitamin D3), prevents cancer progression by reducing cell proliferation, increasing cell differentiation, and inhibiting angiogenesis, among ...
Chun-Yin Huang, Yu-Ting Weng, Po-Chen Li, Nien-Tsu Hsieh, Chun-I Li, Hsiao-Sheng Liu, Ming-Fen Lee   +6 more
doaj   +2 more sources

Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin

Stem Cells International, 2021
Curcumin, as a natural phenolic substance, is extracted from the rhizome of Curcuma longa (turmeric), which is effective in bone healthfulness. Calcitriol is an effective hormone in regulating bone remodeling and mineral homeostasis and immune response ...
Mohammad Samiei, Atefeh Abedi, Simin Sharifi, Solmaz Maleki Dizaj   +3 more
doaj   +2 more sources

Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism

Cells, 2020
Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy.
Ioanna-Maria Gkotinakou, Eleni Kechagia, Kalliopi Pazaitou-Panayiotou, Ilias Mylonis, Panagiotis Liakos, Andreas Tsakalof   +5 more
doaj   +2 more sources

Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1β and TNF-α

Journal of Immunology Research, 2019
Triple-negative breast cancer (TNBC) is one of the most aggressive tumors, with poor prognosis and high metastatic capacity. The aggressive behavior may involve inflammatory processes characterized by deregulation of molecules related to the ...
Isela Martínez-Reza, Lorenza Díaz, David Barrera, Mariana Segovia-Mendoza, Sigifredo Pedraza-Sánchez, Giovanny Soca-Chafre, Fernando Larrea, Rocío García-Becerra   +7 more
doaj   +2 more sources

In vitro evaluation of the immunomodulatory and antibacterial activities of calcitriol (1,25-dihydroxy-vitamin D3) as a potential application for aerobic vaginitis treatment - preliminary study results [PDF]

BMC Microbiology
Background Aerobic vaginitis (AV) is a state of abnormal vaginal microbiota, which is associated with increased numbers of aerobic, enteric bacteria and inflammation of the vaginal epithelium.
Anna Tomusiak-Plebanek, Grażyna Więcek, Edyta Golińska, Magdalena Strus   +3 more
doaj   +2 more sources