Results 51 to 60 of about 49,400 (296)

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease [PDF]

, 2017
The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD ...
Jordi Bover, Juan J. Carrero, null null, Pablo Molina, Pablo Ureña Torres, Philippe Chauveau, Sandro Mazzaferro   +6 more
core   +2 more sources

The outcomes of dexmedetomidine and calcitriol on flap viability [PDF]

Acta Cirúrgica Brasileira, 2020
To evaluate protective effects of dexmedetomidine, calcitriol and their combination.Forty Wistar-albino rats were divided into 4 groups; group of Sham (Group Sham); group of dexmedetomidine (Group DEX); group of calcitriol (Group CAL) and group of dexmedetomidineandcalcitriol (Group DEX-CAL).
Mustafa Sırrı Kotanoğlu, Aylin Akbulut, Koray Gürsoy, Gökhan Koca, Namık Özcan, Nihat Yumuşak, Mehmet Şenes, Gül Kırtıl, Meliha Korkmaz   +8 more
openaire   +6 more sources

Calcitriol suppression of parathyroid hormone fails to improve skeletal properties in an animal model of chronic kidney disease [PDF]

, 2016
BACKGROUND: Chronic kidney disease (CKD) leads to complex metabolic changes and an increased risk of fracture. Currently, calcitriol is the standard of care as it effectively suppresses parathyroid hormone (PTH) levels in CKD patients.
Allen, Matthew R., Brown, Drew M., Chen, Neal X., Hammond, Max A., Moe, Sharon M., Newman, Christopher L., Tian, Nannan, Wallace, Joseph M.   +7 more
core   +1 more source

Integrated Synthesis of Calcitriol and 26,27-Hexadeutero Calcitriol

Pharmaceutical Fronts
Calcitriol (1α,25-dihydroxyvitamin D3, 1), a classical vitamin D drug, is indicated primarily in the treatment of patients with postmenopausal osteoporosis and renal osteodystrophy. In this study, a practical synthesis of calcitriol (1), from readily available commercial vitamin D2 (5) via hub intermediate 18, has been accomplished in 9% overall yield.
Fei Tang, Feng Cui, Gang Yu, Lichun Qi, Qingwen Zhang   +4 more
openaire   +2 more sources

Calcitriol Attenuates Doxorubicin-Induced Cardiac Dysfunction and Inhibits Endothelial-to-Mesenchymal Transition in Mice

Cells, 2019
Doxorubicin (Dox) is an effective anti-neoplasm drug, but its cardiac toxicity limits its clinical use. Endothelial-to-mesenchymal transition (EndMT) has been found to be involved in the process of heart failure.
Tzu-hsien Tsai, Cheng-Jei Lin, C. Hang, Wei‐Yu Chen   +3 more
semanticscholar   +1 more source

Calcitriol inhibits migration and invasion of renal cell carcinoma cells by suppressing Smad2/3‐, STAT3‐ and β‐catenin‐mediated epithelial‐mesenchymal transition

Cancer Science, 2019
Low vitamin D status is associated with progression in patients with renal cell carcinoma (RCC). The present study found that vimentin, a mesenchymal marker, was accordingly upregulated, and E‐cadherin, an epithelial marker, was downregulated in RCC ...
Shen Xu, Zhihui Zhang, Lin Fu, Jin Song, Dongdong Xie, De-Xin Yu, De-xiang Xu, G. Sun   +7 more
semanticscholar   +1 more source

Solid lipid dispersion of calcitriol with enhanced dissolution and stability [PDF]

, 2011
Solid dispersion of calcitriol with lipophilic surfactants and triglycerides was developed by melt-mixing method to modify the release and enhance stability of the drug. The solid dispersions were characterized by differential scanning calorimetry (DSC),
Yuan, Ting, Qin, Lingzhen, Wang, Zhouhua, Nie, Jinyuan, Guo, Zhefei, Li, Ge, Wu, Chuanbin   +6 more
core   +1 more source

A Splice‐Region Variant Causes an Atypical Presentation of GNAS Inactivation Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in GNAS can cause a wide range of diseases including pseudohypoparathyroidism, pseudopseudohypoparathyroidism, McCune‐Albright syndrome, among others. The specific phenotypic features that may be seen are influenced by the variant type and location in the gene, whether it causes loss or gain of function, and whether it is ...
Brandon S. Stone, Swetha Ramadesikan, Regan McGinley, Scott E. Hickey, Leeran B. Dublin‐Ryan, Steven I. Estes, Victoria A. Elliott, Benjamin Karabasz, Jesse M. Hunter, Bimal P. Chaudhari, Richard K. Wilson, Daniel C. Koboldt   +11 more
wiley   +1 more source

Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats

Scientific Reports, 2019
Glycerol injection in rats can lead to rhabdomyolysis, with the release of the intracellular muscle content to the extracellular compartment and acute kidney injury (AKI).
N. Reis, H. D. Francescato, L. F. de Almeida, Cleonice da Silva, R. Costa, T. Coimbra   +5 more
semanticscholar   +1 more source

Preoperative Vitamin D Supplementation to Reduce Hypocalcemia Following Total Thyroidectomy: Systematic Review and Meta‐Analysis of Randomized Clinical Trials

Head &Neck, EarlyView.
ABSTRACT Objective This study aims to determine whether preoperative supplementation of vitamin D reduces the incidence of hypocalcemia following total thyroidectomy. Methods Conducted in conformity with the PRISMA statement, a systematic review and meta‐analysis of randomized clinical trials (RCT) was performed assessing postoperative hypocalcemia and
Luca Canali, Gian Marco Pace, Marika D. Russell, Francesca Gaino, Luca Malvezzi, Gherardo Mazziotti, Andrea Lania, Giuseppe Spriano, Michael Mannstadt, Gregory W. Randolph, Giuseppe Mercante   +10 more
wiley   +1 more source