Results 11 to 20 of about 770,107 (277)
Epigenetic Regulation of Epidermal Differentiation
Epigenomes, 2021 The epidermis is the outer part of the skin that protects the organism from dehydration and shields from external insults. Epidermal cells, called keratinocytes, undergo a series of morphological and metabolic changes that allow them to establish the ...
Wiesława Leśniak
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Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway
Journal of Neuroinflammation, 2022 Highlights LPS-induced neuroinflammation promotes metabolic reprogramming. Neuroinflammation increased glycolytic flow and lactate release. Inhibitors of different glycolytic reactions prevented the inflammatory response. S100B changes suggest a role for
Adriana Fernanda K. Vizuete +8 more
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Frontiers in Neuroanatomy, 2020 In therian mammals, the cerebellum is one of the late developing structures in the brain. Specifically, the proliferation of cerebellar granule cells occurs after birth, and even in humans, the generation of these cells continues during the first year of
Beata Tepper +6 more
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Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
Biomolecules, 2021 Motifs within proteins help us categorize their functions. Intrinsically disordered proteins (IDPs) are rich in short linear motifs, conferring them many different roles.
Estella A. Newcombe +7 more
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Evolutionary Covariant Positions within Calmodulin EF-hand Sequences Promote Ligand Binding [PDF]
, 2018 Intracellular calcium signaling is an essential regulatory mechanism through calcium-mediated signal transduction pathways involved in many cell processes, such as exocytosis, motility, apoptosis, excitability, transcription, and muscle contraction.
Vaidyanathan, Uma
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Site-Directed Mutagenesis and Site-Specific Binding Analysis of Calmodulin (CaM) [PDF]
, 2017 Calcium signaling is a major regulatory system in cells and a crucial part of cell biology. An important element in the decoding of intracellular calcium concentration into downstream processes is the ubiquitous and highly conserved calcium binding ...
Dokic, Yelena
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Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]
, 2008 BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Bates, Declan +4 more
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Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegeneration
Current Issues in Molecular Biology, 2022 Neurodegeneration leads to multiple early changes in cognitive, emotional, and social behaviours and ultimately progresses to dementia. The dysregulation of calcium is one of the earliest potentially initiating events in the development of ...
Danton H. O’Day
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Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]
, 2009 Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Moroz, Olga V. +13 more
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Fungal genomes: suffering with functional annotation errors
IMA Fungus, 2021 Background The genome sequence data of more than 65985 species are publicly available as of October 2021 within the National Center for Biotechnology Information (NCBI) database alone and additional genome sequences are available in other databases and ...
Tapan Kumar Mohanta, Ahmed Al-Harrasi
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