Results 201 to 210 of about 30,912 (250)
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Calcium/Calmodulin-Dependent Protein Kinase II
1990There is a great deal known about the in vitro properties of CaM kinase II, both in terms of its substrate specificity and its regulation by calmodulin and autophosphorylation. Much of this characterization is based on experiments performed with the rat brain isozyme of CaM kinase II, although in the aspects examined to date isozymes of the kinase from
R J, Colbran, T R, Soderling
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Immunochemical localization of calcium/calmodulin‐dependent protein kinase I
Synapse, 1995AbstractCa2+/calmodulin‐dependent protein kinase I (CaM kinase I) was originally identified in rat brain based on its ability to phosphorylate site 1 of synapsin I. Recently a cDNA for the rat brain enzyme has been cloned and the primary structure elucidated [Picciotto et al. (1993), J. Biol. Chem., 268:26512–26521].
PICCIOTTO MR +3 more
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Calcium/Calmodulin-Dependent Protein Kinase Kinase: Identification of Regulatory Domains
Biochemistry, 1997We recently cloned a calmodulin-dependent protein kinase kinase (CaM-KK) which phosphorylates and activates CaM-KI and CaM-KIV [Tokumitsu, H., Enslen, H., and Soderling, T. R. (1995) J. Biol. Chem. 270, 19320-19324]. In the present study, we have identified its regulatory CaM-binding and autoinhibitory domains (CBD and AID, respectively) using a series
H, Tokumitsu +3 more
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Calcium/Calmodulin‐Dependent Protein Kinase II in Squid Synaptosomes
Journal of Neurochemistry, 1987Abstract: The Ca2+/calmodulin (CaM)‐dependent protein kinase II system in squid nervous tissue was investigated. The Ca2+/CaM‐dependent protein kinase II was found to be very active in the synaptosome preparation from optic lobe, where it was associated with the high‐speed particulate fraction.
M, Bass +3 more
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Calcium/calmodulin-dependent protein kinase II and synaptic plasticity
Current Opinion in Neurobiology, 2004A prominent role for calcium/calmodulin-dependent protein kinase II (CaMKII) in regulation of excitatory synaptic transmission was proposed two decades ago when it was identified as a major postsynaptic density protein. Since then, fascinating mechanisms optimized to fine-tune the magnitude and locations of CaMKII activity have been revealed.
Roger J, Colbran, Abigail M, Brown
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Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II
Bioorganic & Medicinal Chemistry, 2012Calcium/calmodulin dependent protein kinase II (CaMKII) is involved in the mechanisms underlying higher order brain functions such as learning and memory. CaMKII participates in pathological glutamate signaling also, since it is activated by calcium influx through the N-methyl-d-aspartate type glutamate receptor (NMDAR).
M, Mayadevi +4 more
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Calcium/calmodulin-dependent protein kinase I in Xenopus laevis
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2003Calcium/calmodulin (CaM) dependent protein kinase I (CaM-KI) is a member of a well-defined multi-functional CaM-K family, but its physiological and developmental functions have yet to be determined. Here, we have cloned two cDNAs encoding CaM-KI from a Xenopus laevis (X. laevis) oocyte cDNA library.
Saneyoshi, T, Shoen Kume, Mikoshiba, K
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Calcium/calmodulin-dependent protein kinases.
Seminars in cancer biology, 1995Ca2+ is widely recognized as an essential intracellular second messenger in eukaryotic systems regulating processes such as muscle contraction, neurotransmitter release, gene expression and cell proliferation. The effects of Ca2+ are frequently mediated via interaction with calmodulin (CaM) and strong evidence indicates, in turn, that the effects of ...
A C, Nairn, M R, Picciotto
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Phosphorylation of neurofilament proteins by endogenous calcium/calmodulin-dependent protein kinase
Biochemical and Biophysical Research Communications, 1985A protein fraction containing neurofilaments was prepared from rat brain cytosol by differential centrifugation and gel filtration chromatography. These preparations were enriched for a calcium/calmodulin-dependent kinase activity that phosphorylated endogenous neurofilament proteins.
M L, Vallano +2 more
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The calcium/calmodulin-dependent protein kinase cascades
2007Abstract Calcium/calmodulin-dependent kinase kinase (CaMKK), CaMKI, and CaMKIV constitute CaMK cascades that have gained increased recognition during the past 10 years for their roles in varied biological functions, including learning and memory, T-cell function, and cell survival.
Felice A. Chow, Anthony R. Means
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