Results 91 to 100 of about 654,231 (380)
Theory and experiment reveal unexpected calcium profiles in one-dimensional systems [PDF]
arXiv, 2013 Calcium is an ubiquitous second messenger that triggers a plethora of key physiological responses. The events are initiated in micro- or nano-sized compartments and determined by the complex interactions with calcium-binding proteins and mechanisms of calcium clearance. Local calcium increases in the vicinity of single channels represent an essentially
arxiv
Regulation of AQP0 water permeability is enhanced by cooperativity. [PDF]
, 2013 Aquaporin 0 (AQP0), essential for lens clarity, is a tetrameric protein composed of four identical monomers, each of which has its own water pore. The water permeability of AQP0 expressed in Xenopus laevis oocytes can be approximately doubled by changes ...
Clemens, Daniel M +2 more
core +1 more source
Calcium Channels and Calcium-Binding Proteins
International Journal of Molecular Sciences, 2023 Signals of nerve impulses are transmitted to excitatory cells to induce the action of organs via the activation of Ca2+ entry through voltage-gated Ca2+ channels (VGCC), which are classified based on their activation threshold into high- and low-voltage activated channels, expressed specifically for each organ [...]
openaire +2 more sources
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement
Cell Reports, 2020 Summary: The secreted protein calcium-activated chloride channel regulator 1 (CLCA1) utilizes a von Willebrand factor type A (VWA) domain to bind to and potentiate the calcium-activated chloride channel TMEM16A.
Kayla N. Berry, Tom J. Brett
doaj
Electrodiffusion with calcium-activated potassium channels in dendritic spine [PDF]
arXiv, 2019 We investigate calcium signaling feedback through calcium-activated potassium channels of a dendritic spine by applying the immersed boundary method with electrodiffusion. We simulate the stochastic gating of such ion channels and the resulting spatial distribution of concentration, current, and membrane voltage within the dendritic spine.
arxiv
Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation [PDF]
, 2017 Objective—Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key mechanism of VC. Recent studies show that IL-18 (interleukin-18) favors
Chen, Jie +7 more
core +1 more source
Mitochondrial calcium channels
FEBS Letters, 2010 Mitochondrial Ca2+ handling plays an important role in energy production and various cellular signaling processes. Mitochondrial Ca2+ uptake is regulated by the mitochondrial Ca2+ uniporter (MCU), at least one non‐MCU Ca2+ channel and possibly a mitochondrial ryanodine receptor. Two distinct mechanisms mediate Ca2+ outward transport, the Na+‐dependent (
openaire +3 more sources
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Calcium channelopathies and intellectual disability: a systematic review
Orphanet Journal of Rare Diseases, 2021 Background Calcium ions are involved in several human cellular processes including corticogenesis, transcription, and synaptogenesis. Nevertheless, the relationship between calcium channelopathies (CCs) and intellectual disability (ID)/global ...
Miriam Kessi +5 more
doaj +1 more source