Results 41 to 50 of about 3,623,918 (405)
Decreased myocardial injury and improved contractility after administration of a peptide derived against the alpha-interacting domain of the L-type calcium channel. [PDF]
, 2014 BackgroundMyocardial infarction remains the leading cause of morbidity and mortality associated with coronary artery disease. The L-type calcium channel (IC a-L) is critical to excitation and contraction.
Hool, Livia C +3 more
core +1 more source
Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers
Nature Communications, 2014 Autophagy deregulation during obesity contributes to the pathogenesis of diverse metabolic disorders. However, without understanding the molecular mechanism of obesity interference in autophagy, development of therapeutic strategies for correcting such ...
Hwan-Woo Park +10 more
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2000 We propose a model of calcium channels that can explain most of their observed properties, including the anomalous mole fraction effect and mutation of the glutamate residues. The structure grossly resembles that of the KcsA potassium channel except for the presence of an extracellular vestibule and a shorter selectivity filter containing four ...
Corry, Ben +3 more
openaire +4 more sources
Cell Reports, 2012 Although calcium influx triggers endocytosis at many synapses and non-neuronal secretory cells, the identity of the calcium channel is unclear. The plasma membrane voltage-dependent calcium channel (VDCC) is a candidate, and it was recently proposed that
Lei Xue +7 more
doaj +1 more source
Treatment for calcium channel blocker poisoning: A systematic review
Clinical toxicology, 2014 Context. Calcium channel blocker poisoning is a common and sometimes life-threatening ingestion. Objective. To evaluate the reported effects of treatments for calcium channel blocker poisoning.
M. St-Onge +13 more
semanticscholar +1 more source
Calcium channels for endocytosis [PDF]
The Journal of Physiology, 2014 Exocytosis and endocytosis need to be tightly balanced to keep cell surface area constant. This is of particular relevance for presynaptic terminals, where endocytosis needs to compensate for the ongoing exocytosis of synaptic vesicle to ultimately guarantee reliable synaptic transmission.
openaire +3 more sources
Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]
, 2012 Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J. +5 more
core +2 more sources
Vacuolar calcium channels [PDF]
Journal of Experimental Botany, 2007 The central vacuole is the largest Ca2+ store in a mature plant cell. Ca2+ release from this store contributes to Ca2+-mediated intracellular signalling in a variety of physiological responses. However, the routes for vacuolar Ca2+ release are not well characterized.
Gerald Schönknecht, Igor Pottosin
openaire +3 more sources
Nature Genetics, 2013 Adrenal aldosterone-producing adenomas (APAs) constitutively produce the salt-retaining hormone aldosterone and are a common cause of severe hypertension. Recurrent mutations in the potassium channel gene KCNJ5 that result in cell depolarization and Ca2+
U. Scholl +27 more
semanticscholar +1 more source
Cortisol modulates calcium release-activated calcium channel gating in fish hepatocytes
Scientific Reports, 2021 Glucocorticoids (GCs) are rapidly released in response to stress and play an important role in the physiological adjustments to re-establish homeostasis.
Chinmayee Das +3 more
doaj +1 more source