Results 81 to 90 of about 295,986 (313)
Journal of Cell Biology, 2009 Thanks to a protein that helps fruit flies remain airborne, researchers have deciphered a key step in synapse maturation. [Fouquet et al.][1] show that the protein forms part of a synaptic structure that clusters the calcium channels necessary for neurotransmitter release.
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Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose Sparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient‐reported swallowing function. This study aimed to explore the feasibility of integrating knowledge‐based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade‐off in prophylactic ...
Laura K. Howard +3 more
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SUMOylation regulates USP5-Cav3.2 calcium channel interactions
Molecular Brain, 2019 Cav3.2 calcium channels play a key role in nociceptive signaling in the primary afferent pain pathway. We have previously reported the regulation of Cav3.2 calcium channels by the deubiquitinase USP5 and its importance for regulating peripheral ...
Agustin Garcia-Caballero +5 more
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The Variation of Excess Base with Depth in the English Channel with reference to the Seasonal Consumption of Calcium by Plankton [PDF]
, 1934 L. H. N. Cooper
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Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose To create and conduct a comprehensive onsite end‐to‐end dosimetry audit to assess treatment accuracy of spine, lung, and soft tissue Stereotactic Body Radiotherapy (SBRT) across Australian and New Zealand (ANZ) radiotherapy centers. Methods The Australian Clinical Dosimetry Service (ACDS) anthropomorphic thorax phantom underwent a CT ...
Maddison Shaw +8 more
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LRRK2 regulates voltage-gated calcium channel function.
Frontiers in Molecular Neuroscience, 2016 Voltage-gated Ca2+ (CaV) channels enable Ca2+ influx in response to membrane depolarization. CaV2.1 channels are localized to the presynaptic membrane of many types of neurons where they are involved in triggering neurotransmitter release.
Cade eBedford +4 more
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The Journal of Cell Biology, 2007 ![][1] Calcium channels (red) cluster at presynaptic termini, but not without SMN (right). A paralyzing disease might best be treated by exciting motoneurons rather than saving them, report [Jablonka et al.][2] The paralysis that occurs in patients with spinal muscular atrophy ...
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CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
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Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden +15 more
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Medical Clinics of North America, 1988 The calcium channel blockers initially were approved for the treatment of classical and variant angina pectoris. Recent studies indicate that these agents also are useful in such diverse conditions as pulmonary and systemic hypertension, hypertrophic cardiomyopathy, arrhythmias, asthma, Raynaud's syndrome, esophageal spasm, myometrial hyperactivity ...
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