What calcium channels remember [PDF]
eLife, 2023 A new mechanism involving intermediate gating states of calcium channels explains how analogue postsynaptic potentials influence neurotransmitter release.
Thomas Kaas +2 more
doaj +2 more sources
Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family [PDF]
Phys. Rev. E 88, 052712 (2013), 2013 We use Brownian dynamics simulations to study the permeation properties of a generic electrostatic model of a biological ion channel as a function of the fixed charge $Q_f$ at its selectivity filter. We reconcile the recently-discovered discrete calcium conduction bands M0 ($Q_f$=1e), M1 (3e), M2 (5e) with the set of sodium conduction bands L0 (0.5-0 ...
Eisenberg, Robert S. +4 more
arxiv +5 more sources
Discrete stochastic modeling of calcium channel dynamics [PDF]
, 1999 We propose a simple discrete stochastic model for calcium dynamics in living cells. Specifically, the calcium concentration distribution is assumed to give rise to a set of probabilities for the opening/closing of channels which release calcium thereby changing those probabilities.
Baer, Markus +3 more
arxiv +3 more sources
Emerging roles of L-type voltage gated and other calcium channels in T lymphocytes. [PDF]
Frontiers in Immunology, 2013 In T lymphocytes, calcium ion controls a variety of biological processes including development, survival, proliferation, and effector functions. These distinct and specific roles are regulated by different calcium signals, which are generated by various ...
Abdallah eBadou +4 more
doaj +3 more sources
The regulation role of calcium channels in mammalian sperm function: a narrative review with a focus on humans and mice [PDF]
PeerJMammalian sperm are characterized as specialized cells, as their transcriptional and translational processes are largely inactive. Emerging researches indicate that Ca2+ serves as a crucial second messenger in the modulation of various sperm ...
Yebin Yang +6 more
doaj +3 more sources
TMEM16A is associated with Voltage-gated Calcium Channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit. [PDF]
Frontiers in Cellular Neuroscience, 2015 Photoreceptors rely upon highly specialized synapses to efficiently transmit signals to multiple postsynaptic targets. Calcium influx in the presynaptic terminal is mediated by voltage-gated calcium channels (VGCC).
Antonella eCaputo +6 more
doaj +4 more sources
Calcium channels as therapeutic targets in head and neck squamous cell carcinoma: current evidence and clinical trials [PDF]
Frontiers in OncologyHead and neck squamous cell carcinoma (HNSCC) originates from the mucosal epithelium of the oral cavity, pharynx, and larynx, and is marked by high rates of recurrence and metastasis.
Jinye Lin +6 more
doaj +2 more sources
Calcium Channels in the Heart: Disease States and Drugs
Cells, 2022 Calcium ions are the major signaling ions in the cells. They regulate muscle contraction, neurotransmitter secretion, cell growth and migration, and the activity of several proteins including enzymes and ion channels and transporters. They participate in
Kajol Shah +4 more
doaj +1 more source
Frontiers in Physiology, 2022 Biochemical and functional studies of ion channels have shown that many of these integral membrane proteins form macromolecular signaling complexes by physically associating with many other proteins.
Kunal R. Shah +4 more
doaj +1 more source
Review the Regulation of Plasma Membrane Calcium Channel in Cancer and Patch Clamp Technique [PDF]
E3S Web of Conferences, 2021 As one of the most versatile and universal second messengers, calcium plays an essential role in cell life. Here we briefly reviewed the research progress of how different calcium channels are located at the cell plasma membrane, including voltage-gated ...
Chen Nanjun, Fang Qigeng
doaj +1 more source