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Calcium channels and calcium channel antagonists
Annals of Neurology, 1987AbstractChanges in free intracellular Ca2+ levels provide signals that allow nerve and muscle cells to respond to a host of external stimuli. A major mechanism for elevating the level of intracellular Ca2+ is the influx of extracellular Ca2+ through voltage‐dependent channels in the cell membrane.
David A. Greenberg, David A. Greenberg
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Calcium, calcium channels, and calcium channel antagonists
Canadian Journal of Physiology and Pharmacology, 1990Voltage-dependent Ca2+ channels are an important pathway for Ca2+ influx in excitable cells. They also represent an important site of action for a therapeutic group of agents, the Ca2+ channel antagonists. These drugs enjoy considerable use in the cardiovascular area including angina, some arrhythmias, hypertension, and peripheral vascular disorders ...
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Calcium channel blockers and calcium channels
2004In 1883, Ringer showed that to get isolated hearts to contract, it was necessary to have Ca2+ ions in the perfusion medium [421]. This was the first demonstration of the critical role of calcium in cellular activity. Remarkably, a hundred years passed before the importance of calcium was recognized in processes other than muscle contraction, and almost
Theophile Godfraind, Eric A. Ertel
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Current Opinion in Nephrology and Hypertension, 1994
A key step in renal calcium reabsorption is dihydropyridine-sensitive calcium entry across the apical membrane of the distal tubule. Electrophysiologic studies have confirmed the existence of calcium channels that may mediate this pathway. Molecular studies of voltage-dependent calcium channels have revealed a surprising degree of heterogeneity.
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A key step in renal calcium reabsorption is dihydropyridine-sensitive calcium entry across the apical membrane of the distal tubule. Electrophysiologic studies have confirmed the existence of calcium channels that may mediate this pathway. Molecular studies of voltage-dependent calcium channels have revealed a surprising degree of heterogeneity.
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Calcium channels in hepatocytes
Journal of Hepatology, 1988In living cells, the concentration of cytosolic Ca :+ ([Ca2+]i) is maintained at a level ranging from 50 to 200 nM. The cytosolic Ca 2+ is actively extruded from the cell by a Ca2+-pump present in the plasma membrane and/or by Ca2+/Na + exchange. In resting cells, Ca 2+ is accumulated essentially in the endoplasmic ' reticulum and, to a lesser extent ...
Jean-Pierre Mauger, Michel Claret
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Annual Review of Pharmacology and Toxicology, 1987
The Ca2+ channel blockers, diltiazem, nifedipine, and vcrapamil, are now well-established members of the therapeutic armamentarium employed in cardiovascular disease including, but not limited to, angina in its several forms, hypertension, some cardiac arrhythmias including supraventricular tachycardia, congestive heart failure, and hypertrophic ...
D J Triggle, R A Janis
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The Ca2+ channel blockers, diltiazem, nifedipine, and vcrapamil, are now well-established members of the therapeutic armamentarium employed in cardiovascular disease including, but not limited to, angina in its several forms, hypertension, some cardiac arrhythmias including supraventricular tachycardia, congestive heart failure, and hypertrophic ...
D J Triggle, R A Janis
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Gating a calcium channel [PDF]
Science, 2016 Structural Biology The type 2 ryanodine receptor (RyR2) controls the release of calcium ions from the sarcoplasmic reticulum in cardiac cells—the initiating step in cardiac muscle contraction. Mutations in RyR2 are associated with cardiac diseases. Peng et al.
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