Results 31 to 40 of about 3,253,102 (352)
Activation of Calcium Channels
Biophysical Journal, 1984 Activation of Ca channels has been described as a Hodgkin-Huxley process in which the time constants have ratios of two or greater (1, 2, 3) or as a three-state linear sequential process with two very different time constants (4). We examined activation by measuring the turn-on and turn-off of macroscopic Ca currents and the discharge of single Ca ...
Arthur Brown +2 more
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Mitogens and Calcium Channels [PDF]
Physiology, 1997 Mitogens and, in particular, growth factors can induce changes in free intracellular Ca2+ concentration by opening voltage-independent cationic channels, with different degrees of Ca2+ selectivity. Recent work has provided preliminary insights into the nature of these channels and their role in the control of cell cycle progression.
LOVISOLO, Davide +3 more
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Frontiers in Cellular Neuroscience, 2019 Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 ...
Jakob J. Gutzmann +2 more
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Medicine, 2003 Overdose of calcium channel blockers is potentially lethal. Verapamil and diltiazem are much more dangerous than dihydropyridines. Hypotension with (verapamil and diltiazem) or without (dihydropyridines) heart block and bradycardia are the most important features.
Ian M Whyte +5 more
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T-type calcium channel: a privileged gate for calcium entry and control of adrenal steroidogenesis
Frontiers in Endocrinology, 2016 Intracellular calcium plays a crucial role in modulating a variety of functions such as muscle contraction, hormone secretion, gene expression or cell growth. Calcium signaling has been however shown to be more complex than initially thought.
Michel Florian Rossier +1 more
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Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. [PDF]
PLoS ONE, 2013 Calcium-activated potassium channels of the KCa1.1 class are known to regulate repolarization of action potential discharge through a molecular association with high voltage-activated calcium channels.
Renata Rehak +5 more
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Store-operated calcium channels in skin
Frontiers in Physiology, 2022 The skin is a complex organ that acts as a protective layer against the external environment. It protects the internal tissues from harmful agents, dehydration, ultraviolet radiation and physical injury as well as conferring thermoregulatory control ...
Declan Manning +3 more
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2000 We propose a model of calcium channels that can explain most of their observed properties, including the anomalous mole fraction effect and mutation of the glutamate residues. The structure grossly resembles that of the KcsA potassium channel except for the presence of an extracellular vestibule and a shorter selectivity filter containing four ...
Corry, Ben +3 more
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Membrane Currents in Airway Smooth Muscle: Mechanisms and Therapeutic Implications
Canadian Respiratory Journal, 1997 Electrophysiological and pharmacological techniques were used to characterize the membrane conductance changes underlying spasmogen-evoked depolarization in airway smooth muscle (ASM).
Luke J Janssen
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CavĪ² surface charged residues contribute to the regulation of neuronal calcium channels
Molecular Brain, 2022 Voltage-gated calcium channels are essential regulators of brain function where they support depolarization-induced calcium entry into neurons. They consist of a pore-forming subunit (CavĪ±1) that requires co-assembly with ancillary subunits to ensure ...
Alexandra Tran-Van-Minh +2 more
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