Results 111 to 120 of about 652,107 (224)

Innovation of plant‐derived extracellular vesicles and interdisciplinary research: From discovery to biomedical applications

open access: yesBMEMat, EarlyView.
Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li   +6 more
wiley   +1 more source

Targeting the Kinesin Eg5 to Monitor siRNA Transfection in Mammalian Cells

open access: yesBioTechniques, 2002
RNA interference, the inhibition of gene expression by double-stranded RNA, provides a powerful tool for functional studies once the sequence of a gene is known.
D. Weil   +5 more
doaj   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

open access: yesBMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu   +8 more
wiley   +1 more source

Electroporation with Calcium or Bleomycin: First Application in an In Vivo Uveal Melanoma Patient-Derived Xenograft Model

open access: yesPharmaceuticals
Uveal melanoma (UM) represents a rare tumor of the uveal tract and is associated with a poor prognosis due to the high risk of metastasis. Despite advances in the treatment of UM, the mortality rate remains high, dictating an urgent need for novel ...
Ralitsa Anastasova   +7 more
doaj   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová   +5 more
wiley   +1 more source

Chemistry Underlying the Behavior of Food and Agricultural Components During Industrial Manufacturing Processes and Its Implications in Quality Assurance, Food Quality, and Food Safety Management: A Systematic Review

open access: yesFood Safety and Health, EarlyView.
Industrial manufacturing processes have transformative effects on the components of food matrix. These transformations in food matrix and components have direct implications for quality assurance (QA), food quality (e.g., nutritional profile and texture), and food safety management (e.g., pathogen control and toxin mitigation). ABSTRACT This systematic
Chinaza Godswill Awuchi
wiley   +1 more source

MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih   +10 more
wiley   +1 more source

Figure S2 from Normal and Malignant Cells Exhibit Differential Responses to Calcium Electroporation

open access: yes, 2017
Figure S2. Light microscope image of colon cancer tumor treated with calcium electroporation HT29 (human colon cancer) tumor treated with 168 mM calcium electroporation and removed 6 days after treatment.
Stine K. Frandsen (14927444)   +6 more
core   +1 more source

DNA Immunotherapy (INO‐3107) Long‐Term Efficacy Supported by Enhanced Immunogenicity in HPV‐6/11 RRP

open access: yesThe Laryngoscope, EarlyView.
Adults with HPV‐6/11‐associated recurrent respiratory papillomatosis (RRP) received DNA immunotherapy INO‐3107 in a Phase 1/2 trial and were followed for one year, with additional clinical follow‐up in a long‐term extension. INO‐3107 was shown to generate increased HPV‐directed T‐cell responses in Year 1 and substantially reduced surgical procedures ...
Milan R. Amin   +15 more
wiley   +1 more source

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