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Neoadjuvant calcium electroporation for potentially curable colorectal cancer
Surgical Endoscopy, 2023The development of new perioperative treatment modalities to activate the immune system in colorectal cancer might have a beneficial effect on reducing the risk of recurrence after surgery. Calcium electroporation is a promising treatment modality that potentially modulates the tumor microenvironment. The aim of this study was to evaluate the safety of
M. Broholm +9 more
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Electroporation Loading of Calcium-Sensitive Dyes Into the CNS
Journal of Neurophysiology, 2005Calcium imaging of neural network function has been limited by the extent of tissue labeled or the time taken for labeling. We now describe the use of electroporation—an established technique for transfecting cells with genes—to load neurons with calcium-sensitive dyes in the isolated spinal cord of the neonatal mouse in vitro.
Agnès, Bonnot +3 more
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Biochemical and Biophysical Research Communications, 1992
Chemotaxis by electroporated rabbit peritoneal neutrophils in the absence of Ca2+ is only slightly different from that in the presence of Ca2+. Pretreatment of neutrophils with quin2-AM causes inhibition of chemotaxis. Calcium antagonists as nitrendipine and verapamil are inhibitory in nanomolar concentrations, while 10(5) times higher concentrations ...
J G, Elferink +2 more
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Chemotaxis by electroporated rabbit peritoneal neutrophils in the absence of Ca2+ is only slightly different from that in the presence of Ca2+. Pretreatment of neutrophils with quin2-AM causes inhibition of chemotaxis. Calcium antagonists as nitrendipine and verapamil are inhibitory in nanomolar concentrations, while 10(5) times higher concentrations ...
J G, Elferink +2 more
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Advancing cancer therapy: Mechanisms, efficacy, and limitations of calcium electroporation
Biochimica Et Biophysica Acta: Reviews on CancerCalcium electroporation, an innovative technique, uses high-voltage pulses to introduce calcium ions into cells, leading to cell death and tumor growth inhibition. This review explores the potential of calcium electroporation as a promising therapeutic approach in cancer treatment.
Jolanta Saczko +2 more
exaly +4 more sources
2022
Electroporation is a method used for local cancer therapy in a form of electrochemotherapy or electroablation [1]. The mechanism of electrochemotherapy is triggered by the process of reversible electroporation; when high intensity electric field increase transmembrane potential of affected cells to a critical value.
Barauskaitė-Šarkinienė, Neringa +3 more
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Electroporation is a method used for local cancer therapy in a form of electrochemotherapy or electroablation [1]. The mechanism of electrochemotherapy is triggered by the process of reversible electroporation; when high intensity electric field increase transmembrane potential of affected cells to a critical value.
Barauskaitė-Šarkinienė, Neringa +3 more
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Calcium electroporation efficiency dependence on calcium concentration and administration time [PDF]
, 2019 Calcium ion distribution between extra and intracellular compartments plays a crucial role in cellular response to various external stress conditions. Necrotic and apoptotic processes are associated with intracellular calcium ion overload, because once calcium ions reach their threshold in the cytoplasm they cause changes in activity of enzymes ...
Navickaitė, Diana +4 more
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A comparison of calcium phosphate coprecipitation and electroporation
Molecular Biotechnology, 1998Plasmid-based transfection assays provide a rapid means to measure homologous and nonhomologous recombination in mammalian cells. Often it is of interest to examine the stimulation of recombination by DNA damage induced by radiation, genotoxic chemicals, or nucleases. Transfection is frequently performed by using calcium phosphate coprecipitation (CPP),
J A, Nickoloff +2 more
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The effect of electroporation on iontophoretic transdermal delivery of calcium regulating hormones
Journal of Controlled Release, 2000Electrically-assisted delivery by iontophoresis and/or electroporation was used in vitro to deliver the calcium regulating hormones, salmon calcitonin (sCT) and parathyroid hormone (1-34) (PTH) through human epidermis. Such delivery could be useful for chronic treatment of post-menopausal osteoporosis and other clinical indications as a superior ...
S L, Chang +4 more
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Single-Cell Electroporation for Measuring In Vivo Calcium Dynamics in Microglia
2019Similar to many nonexcitable cells, microglia utilize intracellular Ca2+ signaling for the communication with each other as well as neurons and astrocytes and for triggering a magnitude of their executive functions. However, in vivo measurements of the intracellular Ca2+ dynamics in microglia have been challenging due to technical reasons.
Bianca, Brawek, Olga, Garaschuk
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Calcium Electroporation: An Overview of an Innovative Cancer Treatment Approach
2019 PhotonIcs & Electromagnetics Research Symposium - Spring (PIERS-Spring), 2019Electroporation (EP) involves the application of short (ms to $\mu\mathrm{s}$ ), high voltage electric pulses to increase the permeability of biological membranes to external ions or molecules. In the clinical practice, reversible EP is used to increase the uptake of chemotherapeutic drugs in local, nonthermal tumor treatment (electrochemotherapy, ECT)
Romeo, Stefania +3 more
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