Results 81 to 90 of about 652,107 (224)

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

Advanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang, Min Li, Junjie Hu, Shoudong Ye, Xin Wang, Xiaobin Xu, Yupeng Wang, Tana Wuren, Qian Ban, Baowei Zhang   +18 more
wiley   +1 more source

Milk of calcium renal cyst and Liesegang structures

Human Pathology: Case Reports, 2019
Liesegang rings are rare and very few cases reported in literature in association with malignancy. Although they have no biologic or clinical significance, unique morphology and unfamiliarity with these structures are often confused with malignancy ...
Prashant Bavi, Jagdish Butany, Korosh Khalili, Runjan Chetty   +3 more
doaj   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Intratumoral Fusogenic Outer Membrane Vesicles Enhance Antitumor Immunity Through Tumor MHC‐I Upregulation and Tumor Bacterization

Advanced Science, EarlyView.
Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu, Jiaxin Zhou, Guihong Lu, Chenjing Zhao, Weixiu Wang, Jichuan Chen, Fengqi Zhang, Fan Zhang, Hai‐Yan Xie, Weidong Nie   +9 more
wiley   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

Calcium electroporation in primary cutaneous marginal zone lymphoma [PDF]

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2021
Stranzenbach, René (Dr. med.), Dörler, Martin (Dr. med.), Scholl, Lisa (Dr. med.), Bechara, Falk Georges (Prof. Dr. med.)   +3 more
openaire   +3 more sources

Enhanced non-viral gene delivery via calcium phosphate/DNA co-precipitates with low-voltage pulse electroporation in NK-92 cells for immunocellular therapy

APL Bioengineering
Achieving high cell transfection efficiency is essential for various cell types in numerous disease applications. However, the efficient introduction of genes into natural killer (NK) cells remains a challenge.
Che-Yung Kuan, I-Hsuan Yang, Chia-Ting Chang, Zhi-Yu Chen, Jhih-Ni Lin, Wei-Ting Kuo, Yu-Ying Lin, Andrew Yueh, Feng-Huei Lin   +8 more
doaj   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Multiple action potentials and complex calcium dynamics following electroporation of S-HEK cells depend on gap junction coupling

Scientific Reports
In recent years, irreversible electroporation has been increasingly used to treat cardiac arrhythmias, an approach termed pulsed field ablation. The mechanisms of how electroporation affects the generation and propagation of action potentials (AP) in the
Tina Batista Napotnik, Anja Blažič, Vid Jan, Klara Bulc Rozman, Rok Šmerc, Lea Rems   +5 more
doaj   +1 more source

Primary Neuronal Culture and Transient Transfection

Bio-Protocol
Primary neuronal culture and transient transfection offer a pair of crucial tools for neuroscience research, providing a controlled environment to study the behavior, function, and interactions of neurons in vitro.
Shun- Tseng, Peng- Chen, Eric Hwang
doaj   +1 more source