Results 141 to 150 of about 6,142,205 (404)

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer [PDF]

, 2019
Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival.
Alzayady, Kamil J., Ando, Hideaki, Bartok, Adam, Bánsághi, Száva, Csordás, György, Golenár, Tünde, Hajnóczky, György, Joseph, Suresh K., Katona, Máté, Mikoshiba, Katsuhiko, Nichtova, Zuzana, Thomas, V. Kaye, Weaver, David, Yule, David I.   +13 more
core   +1 more source

Calcium-Mediated Abiotic Stress Signaling in Roots. [PDF]

, 2016
Roots are subjected to a range of abiotic stresses as they forage for water and nutrients. Cytosolic free calcium is a common second messenger in the signaling of abiotic stress.
Davies, Julia M, Matthus, Elsa, Swarbreck, Stéphanie M, Wilkins, Katie A   +3 more
core   +2 more sources

G protein-coupled receptor-mediated calcium signaling in astrocytes [PDF]

arXiv, 2018
Astrocytes express a large variety of G~protein-coupled receptors (GPCRs) which mediate the transduction of extracellular signals into intracellular calcium responses. This transduction is provided by a complex network of biochemical reactions which mobilizes a wealth of possible calcium-mobilizing second messenger molecules.
arxiv  

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Calcium-sensing receptor: a key target for extracellular calcium signaling in neurons

Frontiers in Physiology, 2016
Though both clinicians and scientists have long recognized the influence of extracellular calcium on the function of muscle and nervous tissue, recent insights reveal that the mechanisms allowing changes in extracellular calcium to alter cellular ...
Brian L Jones, Stephen M Smith, Stephen M Smith   +2 more
doaj   +1 more source

Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. [PDF]

, 2017
Inappropriate activation of mast cells via the FcεRI receptor leads to the release of inflammatory mediators and symptoms of allergic disease. Calcium influx is a critical regulator of mast cell signaling and is required for exocytosis of preformed ...
Alfonso, Alicia, Ashmole, Ashmole, Baba, Bischoff, Capite, Cayouette, Cayouette, Chaudhuri, Chen, Cheng, Cohen, Cruse, Derler, Dietrich, Douglas, Ennis, Estacion, Gilfillan, Gilfillan, Gordon, Hofmann, Hogan, Holowka, Hong, Kirshenbaum, Klein, Kuehn, Lee, Lewis, Liao, Liao, Liou, Ma, Martin-Avila, Medic, Metcalfe, Monet, Okayama, Ong, Ong, Ong, Pani, Pani, Prakriya, Prakriya, Pullen, Riazanski, Rice, Sabatino, Sanmugalingam, Seo, Shi, Siraganian, Souza, Souza, Storch, Suzuki, Vig, Vig, Wareham, Wareham, Washburn, Worley, Wykes, Yeh, Yuan, Zeng   +68 more
core   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

Investigation of Oncogenic RAS and Endoplasmic Reticulum-Mitochondria Calcium Flux and their Relationship in the Context of Tumorigenesis [PDF]

, 2022
Intracellular calcium as a signaling molecule is a pervasive feature of cellular pathways, especially those that manage internal homeostasis and transitions through the cell cycle, so much so that regulated, responsive calcium flux between the ...
Anderson, Emma
core   +2 more sources

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source