Results 151 to 160 of about 1,856,966 (308)
Molecular Mechanism of Calcium Sensing Receptor Mediated Calcium Signaling
Calcium (Ca2+) serves as both a primary and secondary messenger, regulating various biological and pathological functions through calcium dynamics and interacting with crucial calcium-binding proteins like the calcium-sensing receptor (CaSR).
Tian, Li
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Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures
, 2008 Receptors for extracellular nucleotides (the P2X-calcium channels and the phospholipase C-coupled P2Y receptors) play key roles in pain signaling, but little is known on their function in trigerninal ganglia, whose hyperactivation leads to the ...
M. Fumagalli +4 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Calcium signal compartmentalization
Biological Research, 2002 Cytosolic calcium signals are produced by suddenly increasing the concentration of free calcium ions (Ca2+). This can occur by opening channels permeable to Ca2+ either in the surface cell membrane or in the membranes of intracellular organelles containing high Ca2+ concentrations.
openaire +4 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2010 Meeting on New Horizons in Calcium Signaling, Beijing, China, 10-13 October 2010, p ...
Li, GR, Tao, R, Lee, HC
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Integrin-mediated membrane blebbing is dependent on the NHE1 and NCX1 activities. [PDF]
, 2011 Integrin-mediated signal transduction and membrane blebbing have been well studied to modulate cell adhesion, spreading and migration^1-6^. However, the relationship between membrane blebbing and integrin signaling has not been explored.
Wei-Lien Tseng +8 more
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Calcium signaling complexes in microdomains of polarized secretory cells
, 2006 The highly polarized nature of epithelial cells in exocrine glands necessitates targeting, assembly into complexes and confinement of the molecules comprising the Ca2+ signaling apparatus, to cellular microdomains.
신동민, 유형석
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