Results 71 to 80 of about 518,632 (310)

Astroglial calcium signaling displays short-term plasticity and adjusts synaptic efficacy

Frontiers in Cellular Neuroscience, 2015
Astrocytes are dynamic signaling brain elements able to sense neuronal inputs and to respond by complex calcium signals, which are thought to represent their excitability.
Jeremie eSibille, Jonathan eZapata, Jeremie eTeillon, Nathalie eRouach   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Quantification of the density of cooperative neighboring synapses required to evoke endocannabinoid signaling

, 2014
The spatial pattern of synapse activation may impact on synaptic plasticity. This applies to the synaptically-evoked endocannabinoid-mediated short-term depression at the parallel fiber (PF) to Purkinje cell synapse, the occurrence of which requires ...
Pachoud, B, Bergerot, A, Pachoud, B., Knöpfel, T, Sharma, P, Marcaggi, P, Bergerot, A., Marcaggi, P., Sharma, P., Marcaggi, Païkan, Knöpfel, T.   +10 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Hills, Claire E., Bennett, Jeanette, Younis, Mustafa Y. G., Squires, Paul E., Liu, Kuo-Kang, Siamantouras, Eleftherios   +5 more
core   +1 more source

Hormone-stimulated modulation of endocytic trafficking in osteoclasts [PDF]

, 2012
Copyright @ 2012 Stenbeck, Lawrence and Albert. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and ...
Stenbeck, G, Anthony P. Albert, Albert, Anthony P., Lawrence, Kevin M., Lawrence, KM, Kevin M. Lawrence, Gudrun eStenbeck, Stenbeck, Gudrun, Anthony P Albert, Gudrun Stenbeck, Albert, AP, Kevin M Lawrence   +11 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Calcium Signaling In Trypanosomatid Parasites

, 2016
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Calcium ion (Ca2+) is an important second messenger in trypanosomatids and essential for their survival although prolonged high intracellular Ca2+ levels lead to cell death. As other eukaiyotic
Docampo, Guozhong, Roberto; Huang
core   +1 more source