Results 81 to 90 of about 1,971,191 (306)

Inhibition of Akt activity and calcium channel function coordinately drive cell-cell fusion in the BeWO choriocarcinoma placental cell line [PDF]

, 2012
To establish a simple and quantitative live cell fusion assay for placental syncytialization, we generated stable GFP and dsRed expressing fusogenic BeWo cell lines.
Bastie, Claire C., Jeffrey E Pessin, Dimitris Grammatopoulos, Lydia Tesfa (33289), Bastie Claire C., Dimitris Grammatopoulos (187265), Claire C. Bastie (187271), Grammatopoulos Dimitris, Yamada, Eijiro, Grammatopoulos, Dimitris, Eijiro Yamada, Tesfa, Lydia, Eijiro Yamada (187269), Lydia Tesfa, Tesfa Lydia, Claire C Bastie, Vatish Manu, Manu Vatish (187260), Yamada Eijiro, Vatish, Manu, Manu Vatish, Pessin Jeffrey E., Pessin, Jeffrey E., Jeffrey E. Pessin (187274)   +23 more
core   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Mitochondrial DNA mutations affect calcium handling in differentiated neurons. [PDF]

, 2010
Contains fulltext : 88975.pdf (Publisher’s version ) (Closed access)Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood ...
Enriquez, J.A., Turnbull, D.M., Smulders-Srinivasan, Tora, Lightowlers, R.N., Trevelyan, A.J., Nooteboom, Marco, Nooteboom, M., Smulders-Srinivasan, T.K., Acin-Perez, Rebeca, Whittington, Miles A., Lightowlers, Robert N., Whittington, M.A., Turnbull, Doug, Kirby, Denise M., Trevelyan, Andrew, Smulders-Srinivasan, Tora K.; id_orcid, Acin-Perez, Rebecca, Trevelyan, Andrew J., Turnbull, Doug M., Acin-Perez, R., Enriquez, José Antonio, Kirby, Denise, Lightowlers, Robert, Kirby, D.M., Enriquez, Jose, Whittington, Miles   +25 more
core   +1 more source

Calcium signaling in cholangiocytes

World Journal of Gastroenterology, 2006
Cytosolic Ca2+ is an important second messenger in virtually every type of cell. Moreover, Ca2+ generally regulates multiple activities within individual cells. This article reviews the cellular machinery that is responsible for Ca2+ signaling in cholangiocytes.
Noritaka, Minagawa, Barbara-E, Ehrlich, Michael-H, Nathanson   +2 more
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis

Molecular Metabolism
Objective: Hepatic Ca2+ signaling has been identified as a crucial key factor in driving gluconeogenesis. The involvement of mitochondria in hormone-induced Ca2+ signaling and their contribution to metabolic activity remain, however, poorly understood ...
Mahmoud Taha, Essam A. Assali, Tsipi Ben-Kasus Nissim, Grace E. Stutzmann, Orian S. Shirihai, Michal Hershfinkel, Israel Sekler   +6 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Calcium Signaling In Trypanosomatid Parasites

, 2016
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Calcium ion (Ca2+) is an important second messenger in trypanosomatids and essential for their survival although prolonged high intracellular Ca2+ levels lead to cell death. As other eukaiyotic
Docampo, Guozhong, Roberto; Huang
core   +1 more source

Study of calcium sparks in skeletal and smooth muscle cells in normal and pathological conditions [PDF]

, 2016
mTOR signaling influence a wide range of cellular process including protein synthesis (Iadevaia et al., 2012; Ma and Blenis, 2009; Thoreen et al., 2012), lipids synthesis (Lamming and Sabatini, 2013), transcription (Dibble and Manning, 2013; Vazquez ...
López, Rubén
core   +1 more source

Calcium-Induced Calcium Release during Action Potential Firing in Developing Inner Hair Cells [PDF]

, 2015
In the mature auditory system, inner hair cells (IHCs) convert sound-induced vibrations into electrical signals that are relayed to the central nervous system via auditory afferents.
Radu Iosub (21829730), Daniele Avitabile (213626), Lisa Grant (21829733), Helen J. Kennedy (21829736), Krasimira Tsaneva-Atanasova (144624)   +4 more
core   +3 more sources