Results 81 to 90 of about 6,142,205 (404)

GABA\u3csub\u3eB\u3c/sub\u3e Receptors Couple to Gα\u3csub\u3eq\u3c/sub\u3e to Mediate Increases in Voltage-Dependent Calcium Current During Development [PDF]

, 2015
Metabotropic GABAB receptors are known to modulate the activity of voltage-dependent calcium channels. Previously, we have shown that GABAB receptors couple to a non-Gi/o G-protein to enhance calcium influx through L-type calcium channels by activating ...
Karls, Andrew S., Mynlieff, Michelle
core   +1 more source

Calpain 3 and CaMKIIβ signaling are required to induce HSP70 necessary for adaptive muscle growth after atrophy. [PDF]

, 2018
Mutations in CAPN3 cause autosomal recessive limb girdle muscular dystrophy 2A. Calpain 3 (CAPN3) is a calcium dependent protease residing in the myofibrillar, cytosolic and triad fractions of skeletal muscle.
Eskin, Ascia, Kramerova, Irina, Nelson, Stanley F, Spencer, Melissa J, Torres, Jorge A   +4 more
core   +1 more source

Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids

Journal of Virology, 2019
Human cytomegalovirus (HCMV) replicates in several cell types throughout the body, causing disease in the absence of an effective immune response. Studies on HCMV require cultured human cells and tissues due to species specificity.
Samantha L. Sison, Benjamin S. O’Brien, Amanda Johnson, Emily R. Seminary, S. Terhune, A. Ebert   +5 more
semanticscholar   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic Cancer

Cells, 2021
Pancreatic ductal adenocarcinoma (PDAC) displays a particularly poor prognosis and low survival rate, mainly due to late diagnosis and high incidence of chemotherapy resistance. Genomic aberrations, together with changes in the epigenomic profile, elicit
Ana P. Kutschat, Steven A. Johnsen, Feda H. Hamdan   +2 more
doaj   +1 more source

Emergent three-dimensional sperm motility: Coupling calcium dynamics and preferred curvature in a Kirchhoff rod model [PDF]

Mathematical Medicine and Biology: A Journal of the IMA, dqy015, 16 October 2018, 2018
Changes in calcium concentration along the sperm flagellum regulate sperm motility and hyperactivation, characterized by an increased flagellar bend amplitude and beat asymmetry, enabling the sperm to reach and penetrate the ovum (egg). The signaling pathways by which calcium increases within the flagellum are well established.
arxiv   +1 more source

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum

Scientific Reports, 2019
Like many viruses, rotavirus (RV) dysregulates calcium homeostasis by elevating cytosolic calcium ([Ca2+]cyt) and decreasing endoplasmic reticulum (ER) stores.
Alexandra L Chang-Graham, Jacob L Perry, Alicia C. Strtak, Nina K Ramachandran, Jeanette M. Criglar, Asha A. Philip, J. Patton, M. Estes, Joseph M. Hyser   +8 more
semanticscholar   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

2′-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca2+ concentrations

Frontiers in Immunology
TRPM2 is a Ca2+ permeable, non-selective cation channel in the plasma membrane that is involved in the innate immune response regulating, for example, chemotaxis in neutrophils and cytokine secretion in monocytes and macrophages.
Jelena Pick, Simon Sander, Stefanie Etzold, Anette Rosche, Henning Tidow, Andreas H. Guse, Ralf Fliegert   +6 more
doaj   +1 more source

The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease.

Physiological Reviews, 2016
Many cellular functions are regulated by calcium (Ca(2+)) signals that are generated by different signaling pathways. One of these is the inositol 1,4,5-trisphosphate/calcium (InsP3/Ca(2+)) signaling pathway that operates through either primary or ...
M. Berridge
semanticscholar   +1 more source