Results 161 to 170 of about 77,245 (243)

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, Volume 183, Issue 15, Page 4321-4343, August 2026.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

A Ca²⁺/Calmodulin-Interacting IQD Hub in Tartary Buckwheat: Genome-Wide <i>FtIQD</i> Analysis and Characterization of <i>FtIQD19</i>. [PDF]

Plants (Basel)
Chen G, Wu C, Zhao Z, Liang Y, Wang J, Li Z, Li Z, Yue X.   +7 more
europepmc   +1 more source

Genetics of Flooding Tolerance in an F2 Miscanthus sacchariflorus ssp. lutarioriparius × M. sinensis Population

GCB Bioenergy, Volume 18, Issue 8, August 2026.
An experiment to map flooding tolerance in Miscanthus ×giganteus was conducted. Two phenotyping protocols (A and B) and different pipelines to call SNPs were used. TASSEL‐GBSv2 resulted in a genetic map with smaller QTL intervals than the other maps.
D. Zerpa‐Catanho, L. Xiao, N. LaBonte, Y. Yoshinaga, M. Blow, K. Barry, X. Kuang, E. Cebert, T. Mitros, D. Rokhsar, K. Swaminathan, E. J. Sacks   +11 more
wiley   +1 more source

Cis-regulatory elements in CAMTA-mediated stress signalling: mechanisms and prospects for CRISPR-based crop improvement. [PDF]

Front Plant Sci
Gain H, Banerjee J.
europepmc   +1 more source

Inhibiting HIF‐1α‐Induced miR‐663b Improves Pulmonary Arterial Hypertension by Reducing Dysfunctions of PASMCs Through Repressing Sirt1‐ZBP1‐Mediated PANoptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a progressive disease characterised by vascular remodelling. Inflammatory responses and oxidative stress have been shown to contribute to its progression. This study investigated the effects of a novel HIF‐1α‐miR‐663b axis on pulmonary arterial smooth muscle inflammation, oxidative stress and apoptosis ...
Le Shen, Honghong Ma, Yang Yu, Yan Xu, Qun Yuan, Xia Zhao, Bing Zhuan   +6 more
wiley   +1 more source

Phenotypic expansion of CALM1/2-associated disorders to include neurologic phenotypes without arrhythmia. [PDF]

Hum Mol Genet
Hoang HD, Spillmann RC, Wegner DJ, Tedesco MG, Brohus M, Novelli A, Stregapede F, Rogaia D, Troiani S, Lesinski J, Yuan W, Fielder SM, Zhang B, Morrison S, Regmi S, Foti MRS, Baldridge D, Silverman GA, Undiagnosed Diseases Network, Shea P, Dickson P, Wambach JA, Overgaard MT, Jensen HH, Olsen A, Prontera P, Shashi V, Pak SC, Schedl T.   +28 more
europepmc   +1 more source

Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance

New Phytologist, Volume 251, Issue 3, Page 975-995, August 2026.
Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap, Arash Fazeli, Ali Bandehagh, Nicolas L. Taylor   +3 more
wiley   +1 more source

Ectopic Expression of ScALDH21 From a Desert Moss Enhances Cotton Resistance to Verticillium Wilt via the Modulation of Jasmonates and Phenylpropanoid Pathways

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4916-4932, August 2026.
ABSTRACT Biotic stresses, particularly Verticillium wilt (VW), lead to a global decline in cotton yields. Here, we demonstrate that ectopic expression of ScALDH21, a gene from the desiccation‐tolerant moss Syntrichia caninervis Mitt. and absent in angiosperms, enhances cotton's resistance to VW.
Honglan Yang, Xiaoshuang Li, Tohir A. Bozorov, Jianwei Zhang, Aerguli Jiamahate, Dawei Zhang, Jiancheng Wang, Qilin Yang, Zongrang Liu, Dina Mahesati, Haijiang Xu, Shuangxia Jin, Daoyuan Zhang, Yongqiang Dai   +13 more
wiley   +1 more source

High mobility group motif proteins' role in fibrosis, inflammation, and vascular injury in systemic sclerosis. [PDF]

J Mol Med (Berl)
Mendoza FA, Piera-Velazquez S, Jimenez SA.   +2 more
europepmc   +1 more source

Negative Regulators of Rice Agronomic Traits: Functional Insights and Applications in Genome Editing‐Based Breeding

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4984-5001, August 2026.
ABSTRACT Rice is the staple crop for more than half of the global population, and improving grain yield, grain quality, and stress resistance remain central goals of modern rice breeding. Among current precision breeding strategies, genome editing has created new opportunities for crop improvement, but its success depends heavily on the selection of ...
Wenhao Wu, Feng Jin, Huaxiang Xu, Ranran Liao, Zhongming Fang   +4 more
wiley   +1 more source