Adipocyte Calpain‐2 Deficiency Reduces Obesity‐Accelerated Abdominal Aortic Aneurysm Formation in Mice [PDF]
FASEB BioAdvancesAbdominal adiposity is associated with increased risk of abdominal aortic aneurysm (AAA) development. Calpains are non‐lysosomal calcium‐dependent cysteine proteases that are highly expressed in human and experimental AAAs.
Ana Clara Frony +6 more
doaj +2 more sources
Calpain in Traumatic Brain Injury: From Cinderella to Central Player [PDF]
CellsTraumatic Brain Injury (TBI) is a major global health concern and a leading cause of death and disability, especially in young adults. It triggers complex secondary injury cascades, e.g., calcium dysregulation, mitochondrial dysfunction and protease ...
Carla Schallerer +3 more
doaj +2 more sources
Neuroprotective Effects of Calpain Inhibition in Parkinson’s Disease: Insights from Cellular and Murine Models [PDF]
CellsParkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, and key pathways such as neuroinflammation, oxidative stress, and autophagy are believed to significantly contribute to the mechanisms of ...
Vandana Zaman +5 more
doaj +2 more sources
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. [PDF]
PLoS ONE, 2012 Calpains are calcium regulated cysteine proteases that have been described in a wide range of cellular processes, including apoptosis, migration and cell cycle regulation. In addition, calpains have been implicated in differentiation, but their impact on
Daniela M Santos +4 more
doaj +1 more source
Calpains in Cyanobacteria and the Origin of Calpains
Scientific Reports, 2022 Abstract Calpains are cysteine proteases involved in many cellular processes. They are an ancient and large superfamily of enzymes responsible for the cleavage and irreversible modification of a large variety of substrates. They have been intensively studied in humans and other mammals, but information about calpains in bacteria is scarce ...
Dominika Vešelényiová +5 more
openaire +3 more sources
Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. [PDF]
PLoS ONE, 2013 Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice.
Venkateswaran Subramanian +5 more
doaj +1 more source
Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology
Neurobiology of Disease, 2021 Calpain has been proposed to play a critical role in the development of epilepsy. Here we used conditional calpain-2 knock-out (C2CKO) mice in a C57/Bl6 background and a selective calpain-2 inhibitor to analyze the role of calpain-2 in epilepsy ...
Yubin Wang +5 more
doaj +1 more source
Biology Open, 2020 Calpain-3 (CAPN3) is a muscle-specific type of calpain whose protease activity is triggered by Ca2+. Here, we developed CAPN3 sensor probes (SPs) to detect activated-CAPN3 using a fluorescence/Förster resonance energy transfer (FRET) technique.
Koichi Ojima +6 more
doaj +1 more source
Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide. [PDF]
PLoS ONE, 2011 Calpain proteases drive intracellular signal transduction via specific proteolysis of multiple substrates upon Ca(2+)-induced activation. Recently, dUTPase, an enzyme essential to maintain genomic integrity, was identified as a physiological calpain ...
Zoltán Bozóky +6 more
doaj +1 more source
Biomolecules, 2023 Inherited retinal degeneration (IRD) represents a diverse group of gene mutation-induced blinding diseases. In IRD, the loss of photoreceptors is often connected to excessive activation of histone-deacetylase (HDAC), poly-ADP-ribose-polymerase (PARP ...
Yujie Dong +6 more
doaj +1 more source