Results 11 to 20 of about 26,870 (178)
Changes in neurodegeneration-related miRNAs in brains from CAPN1−/− mice
BBA Advances, 2021 Calpain-1 knock-out (KO) mice exhibit enhanced susceptibility to neurodegeneration due to the lack of the neuroprotective function of calpain-1. Dicer has been shown to play a fundamental role in the biogenesis of most miRNAs.
Wenyue Su +3 more
doaj +1 more source
Cells, 2020 Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the understanding of the functions of two ubiquitous calpain isoforms, calpain-1 and calpain-2, in the brain ...
Yubin Wang +3 more
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Calpain: the regulatory point of myocardial ischemia-reperfusion injury
Frontiers in Cardiovascular Medicine, 2023 Calpain is a conserved cysteine protease readily expressed in several mammalian tissues, which is usually activated by Ca2+ and with maximum activity at neutral pH.
Guo-Yang Liu +20 more
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Scientific Reports, 2022 Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific proteolytic target and essential structural protein inside Ca2+ release units required for excitation ...
Gunnar Weninger +9 more
doaj +1 more source
Neurobiology of Disease, 2016 Calpain has been shown to be involved in neurodegeneration, and in particular in retinal ganglion cell (RGC) death resulting from increased intraocular pressure (IOP) and ischemia.
Yubin Wang +9 more
doaj +1 more source
GPS-CCD: a novel computational program for the prediction of calpain cleavage sites. [PDF]
PLoS ONE, 2011 As one of the most essential post-translational modifications (PTMs) of proteins, proteolysis, especially calpain-mediated cleavage, plays an important role in many biological processes, including cell death/apoptosis, cytoskeletal remodeling, and the ...
Zexian Liu +5 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Objectives: The goal of our bioinformatics study was to comprehensively analyze the association between the whole calpain family members and the progression and prognosis of hepatocellular carcinoma (HCC).Methods: The data were collected from The Cancer ...
Dongjun Dai +13 more
doaj +1 more source
An eccentric calpain, CAPN3/p94/calpain-3
Biochimie, 2016 Calpains are Ca(2+)-regulated proteolytic enzymes that are involved in a variety of biological phenomena. Calpains process substrates by limited proteolysis to modulate various protein functions in the cell, and are thus called "modulator proteases." CAPN3, previously called p94 or calpain-3, has unique features that are not found in any of the other ...
Ono, Yasuko +4 more
openaire +2 more sources
Cell Discovery, 2023 Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of ...
Jaiprakash Sharma +9 more
doaj +1 more source
Activation of calpain-1 in human carotid artery atherosclerotic lesions
BMC Cardiovascular Disorders, 2009 Background In a previous study, we observed that oxidized low-density lipoprotein-induced death of endothelial cells was calpain-1-dependent. The purpose of the present paper was to study the possible activation of calpain in human carotid plaques, and ...
Pedro Luis M +7 more
doaj +1 more source