Results 11 to 20 of about 26,568 (204)
Possible Regulation of the Conventional Calpain System by Skeletal Muscle-specific Calpain, p94/Calpain 3 [PDF]
Journal of Biological Chemistry, 2004 p94 (also called calpain 3) is the skeletal muscle-specific calpain and is considered to be a "modulator protease" in various cellular processes. Analysis of p94 at the protein level is an urgent issue because the loss of p94 protease activity causes limb-girdle muscular dystrophy type 2A. In this study, we enzymatically characterized one alternatively
Yasuko, Ono +8 more
openaire +2 more sources
Calpain 3: a key regulator of the sarcomere? [PDF]
The FEBS Journal, 2006 Calpain 3 is a 94‐kDa calcium‐dependent cysteine protease mainly expressed in skeletal muscle. In this tissue, it localizes at several regions of the sarcomere through binding to the giant protein, titin. Loss‐of‐function mutations in the calpain 3 gene have been associated with limb‐girdle muscular dystrophy type 2A (LGMD2A), a common form of muscular
Bartoli, Marc +2 more
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Galectin-3 secretion and tyrosine phosphorylation is dependent on the calpain small subunit, Calpain 4 [PDF]
Biochemical and Biophysical Research Communications, 2011 Cell adhesion and migration are important events that occur during embryonic development, immune surveillance, wound healing and in tumor metastasis. It is a multi-step process that involves both mechanical and biochemical signaling that results in cell protrusion, adhesion, contraction and retraction.
Shalini, Menon +2 more
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A single c.1715G>C calpain 3 gene variant causes dominant calpainopathy with loss of calpain 3 expression and activity [PDF]
Human Mutation, 2020 AbstractRecessively inherited limb girdle muscular dystrophy (LGMD) type 2A is the most common LGMD worldwide. Here, we report the first single missense variant in CAPN3 causing dominantly inherited calpainopathy. A 43‐year‐old proband, his father and two sons were heterozygous for a c.1715G>C p.(Arg572Pro) variant in CAPN3.
John Vissing +6 more
openaire +4 more sources
BMC Musculoskeletal Disorders, 2012 Background Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting.
Hauerslev Simon +5 more
doaj +1 more source
An eccentric calpain, CAPN3/p94/calpain-3
Biochimie, 2016 Calpains are Ca(2+)-regulated proteolytic enzymes that are involved in a variety of biological phenomena. Calpains process substrates by limited proteolysis to modulate various protein functions in the cell, and are thus called "modulator proteases." CAPN3, previously called p94 or calpain-3, has unique features that are not found in any of the other ...
Ono, Yasuko +4 more
openaire +2 more sources
Frontiers in Medicine, 2022 Renal ischemia/reperfusion injury is a major contributor of acute kidney injury (AKI), leading to renal cell necrosis, apoptosis, and inflammation. Calpains, a family of Ca2+-dependent cysteine proteases, play a pivotal role in the pathogenesis of renal ...
Yong Wu +6 more
doaj +1 more source
Homodimerization of calpain 3 penta-EF-hand domain [PDF]
Biochemical Journal, 2005 Calpains 1 and 2 are heterodimeric proteases in which large (relative molecular mass Mr 80000) and small (Mr 28000) subunits are linked through their respective PEF (penta-EF-hand) domains. The skeletal muscle-specific calpain 3 is believed not to form a heterodimer with the small subunit but might homodimerize through its PEF domain.
Ravikiran, Ravulapalli +3 more
openaire +2 more sources
Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway
Neural Plasticity, 2022 Long-term hypoxia can induce oxidative stress and apoptosis in hippocampal neurons that can lead to brain injury diseases. Astragaloside IV (AS-IV) is widely used in the antiapoptotic therapy of brain injury diseases.
Yan Meng +8 more
doaj +1 more source
M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation
Frontiers in Molecular Neuroscience, 2018 Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan +6 more
doaj +1 more source