Results 21 to 30 of about 26,568 (204)
Redox Biology, 2021 Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, an unintended consequence of prolonged MV is the rapid development of diaphragmatic atrophy and contractile dysfunction, known as ventilator ...
Hayden W. Hyatt +5 more
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Cancer Cell International, 2023 Background Glioblastoma multiforme (GBM) is characterized by an unfavorable prognosis for patients affected. During standard-of-care chemotherapy using temozolomide (TMZ), tumors acquire resistance thereby causing tumor recurrence.
Maren Nicole Stillger +8 more
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Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology
Neurobiology of Disease, 2010 Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic neuronal function. However, mitochondrial-mediated-calcium homeostasis alterations may lead to its pathologic activation that jeopardizes neuronal structure and ...
A. Raquel Esteves +4 more
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Asian Journal of Andrology, 2018 Calpain activation contributes to hyperglycemia-induced endothelial dysfunction and apoptosis. This study was designed to investigate the role of calpain inhibition in improving diabetic erectile dysfunction (ED) in mice. Thirty-eight-week-old male C57BL/
Hao Li +4 more
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Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. [PDF]
PLoS ONE, 2015 Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle. In human melanoma cell lines and biopsies, we previously identified two novel splicing variants (hMp78 and hMp84) of Calpain-
Daniele Moretti +5 more
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Frontiers in Neurology, 2021 We present a patient who had two allogeneic bone marrow transplantations for acute lymphocytic leukemia. She developed slowly progressive limb-girdle weakness in the context of other symptoms of graft-vs.-host disease (GVHD).
Kristina Martens +6 more
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Calpain activates caspase‐3 during UV‐induced neuronal death but only calpain is necessary for death [PDF]
Journal of Neurochemistry, 2002 AbstractWhile caspases have been strongly implicated in delayed neuronal death in a variety of experimental paradigms, other proteases such as calpain can also contribute to neuronal death. To evaluate the relative roles of caspase and calpain, we used a model system wherein UV treatment induced moderate or severe delayed cortical neuronal death, as ...
Adrian T, McCollum +2 more
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Cellular Physiology and Biochemistry, 2015 Aims: The aim of this study was to determine whether calpain is involved in Cl- -induced myocardial ischemia/reperfusion (I/R) injury. Methods: Isolated rat hearts were subjected to either 45 min of global no-flow ischemia followed by reperfusion or ...
Jian-Ying Zhang +7 more
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Arthritis Research & Therapy, 2022 Background Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosis (SSc).
Li Zhang +8 more
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Effects of Yam and Diosgenin on Calpain Systems in Skeletal Muscle of Ovariectomized Rats
Taiwanese Journal of Obstetrics & Gynecology, 2008 Objective: Yam or diosgenin (extracted from the root of wild yam) is traditionally used for hormone replacement in menopausal women. Calpains are crucially related to the degradation of myofibrillar proteins in skeletal muscle.
Kung-Hao Hsu +4 more
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